Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds
Actinomycetes provide a potentially limitless source of novel bioactive compound, possessing a wide range of potential therapeutic uses. Around 25,000 microbial secondary metabolites have been recognized; actinomycetes produce some 75%, of them, with fungi yielding 15%, Bacillus spp. 6%, and other b...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364723003932 |
| _version_ | 1797630616487854080 |
|---|---|
| author | Arunachalam Chinnathambi Saleh H. Salmen Maged A. Al-Garadi Milton Wainwright Sulaiman Ali Alharbi |
| author_facet | Arunachalam Chinnathambi Saleh H. Salmen Maged A. Al-Garadi Milton Wainwright Sulaiman Ali Alharbi |
| author_sort | Arunachalam Chinnathambi |
| collection | DOAJ |
| description | Actinomycetes provide a potentially limitless source of novel bioactive compound, possessing a wide range of potential therapeutic uses. Around 25,000 microbial secondary metabolites have been recognized; actinomycetes produce some 75%, of them, with fungi yielding 15%, Bacillus spp. 6%, and other bacteria producing around 1–3%. Species of Streptomyces provide 50–60 percent of the known antibiotics. Over the last seventy or so years, a vast array of microorganisms has been isolated from soils and other readily accessible environments and the screened for antibiotics. Such screening programs have significantly reduced the likelihood that novel antimicrobial compounds, particularly active against drug resistant species, will now be found. Fortunately, unusual marine environments may act as a future source of actinomycetes and other microorganisms capable of producing new secondary metabolite possessing antifungal, antibacterial, anticancer, insecticidal, enzyme inhibitory and other therapeutic properties. The aim of this review is to highlight marine actinomycetes as a novel source of such potentially critical novel antibiotic and bioactive compounds. |
| first_indexed | 2024-03-11T11:10:41Z |
| format | Article |
| id | doaj.art-8b2aed3d9ebd4b339baf654381756f3d |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-03-11T11:10:41Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-8b2aed3d9ebd4b339baf654381756f3d2023-11-12T04:39:35ZengElsevierJournal of King Saud University: Science1018-36472023-12-01359102931Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compoundsArunachalam Chinnathambi0Saleh H. Salmen1Maged A. Al-Garadi2Milton Wainwright3Sulaiman Ali Alharbi4Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh 11451, Saudi ArabiaDepartment of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi ArabiaDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UKDepartment of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh 11451, Saudi Arabia; Corresponding author.Actinomycetes provide a potentially limitless source of novel bioactive compound, possessing a wide range of potential therapeutic uses. Around 25,000 microbial secondary metabolites have been recognized; actinomycetes produce some 75%, of them, with fungi yielding 15%, Bacillus spp. 6%, and other bacteria producing around 1–3%. Species of Streptomyces provide 50–60 percent of the known antibiotics. Over the last seventy or so years, a vast array of microorganisms has been isolated from soils and other readily accessible environments and the screened for antibiotics. Such screening programs have significantly reduced the likelihood that novel antimicrobial compounds, particularly active against drug resistant species, will now be found. Fortunately, unusual marine environments may act as a future source of actinomycetes and other microorganisms capable of producing new secondary metabolite possessing antifungal, antibacterial, anticancer, insecticidal, enzyme inhibitory and other therapeutic properties. The aim of this review is to highlight marine actinomycetes as a novel source of such potentially critical novel antibiotic and bioactive compounds.http://www.sciencedirect.com/science/article/pii/S1018364723003932Bioactive compoundsAntibioticMarine Actinomycetes |
| spellingShingle | Arunachalam Chinnathambi Saleh H. Salmen Maged A. Al-Garadi Milton Wainwright Sulaiman Ali Alharbi Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds Journal of King Saud University: Science Bioactive compounds Antibiotic Marine Actinomycetes |
| title | Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds |
| title_full | Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds |
| title_fullStr | Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds |
| title_full_unstemmed | Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds |
| title_short | Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds |
| title_sort | marine actinomycetes an endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds |
| topic | Bioactive compounds Antibiotic Marine Actinomycetes |
| url | http://www.sciencedirect.com/science/article/pii/S1018364723003932 |
| work_keys_str_mv | AT arunachalamchinnathambi marineactinomycetesanendlesssourceofpotentiallytherapeuticnovelsecondarymetabolitesandotherbioactivecompounds AT salehhsalmen marineactinomycetesanendlesssourceofpotentiallytherapeuticnovelsecondarymetabolitesandotherbioactivecompounds AT magedaalgaradi marineactinomycetesanendlesssourceofpotentiallytherapeuticnovelsecondarymetabolitesandotherbioactivecompounds AT miltonwainwright marineactinomycetesanendlesssourceofpotentiallytherapeuticnovelsecondarymetabolitesandotherbioactivecompounds AT sulaimanalialharbi marineactinomycetesanendlesssourceofpotentiallytherapeuticnovelsecondarymetabolitesandotherbioactivecompounds |