Design and Synthesis of Hybrid Compounds as Epigenetic Modifiers

Design and Synthesis of Hybrid Compounds as Epigenetic Modifiers

Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains (BET) are involved in viral replication and the host response. In the present s...

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Bibliographic Details
Main Authors: Juliana Romano Lopes, Igor Muccilo Prokopczyk, Max Gerlack, Chung Man Chin, Jean Leandro Dos Santos
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
histone deacetylase
bromodomain
epigenetic
polypharmacology
hybrid
drug design
Online Access:https://www.mdpi.com/1424-8247/14/12/1308

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