Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia
Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for th...
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/1999-4915/14/4/751 |
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| author | Megumi Kato Naoki Imaizumi Reiko Tanaka Mariko Mizuguchi Masaki Hayashi Takashi Miyagi Junnosuke Uchihara Kazuiku Ohshiro Junpei Todoroki Kennosuke Karube Hiroaki Masuzaki Yuetsu Tanaka Takuya Fukushima |
| author_facet | Megumi Kato Naoki Imaizumi Reiko Tanaka Mariko Mizuguchi Masaki Hayashi Takashi Miyagi Junnosuke Uchihara Kazuiku Ohshiro Junpei Todoroki Kennosuke Karube Hiroaki Masuzaki Yuetsu Tanaka Takuya Fukushima |
| author_sort | Megumi Kato |
| collection | DOAJ |
| description | Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for the diagnosis or prediction of the onset of acute ATL, we examined the plasma levels of sTNFR2 in a large number of specimens obtained from a cohort of ATL patients and asymptomatic human T-cell leukemia virus type 1 (HTLV-1) carriers (ACs) and compared them to those of other candidate ATL biomarkers (sCD25, sOX40, and IL-10) by enzyme-linked immunosorbent assays (ELISA) and HTLV-1 proviral loads. We observed that sTNFR2 levels were significantly elevated in acute ATL patients compared to ACs and patients with other types of ATL (chronic, smoldering, and lymphoma). Importantly, sTNFR2 levels were significantly correlated with those of sCD25, sOX40, and IL-10, as well as proviral loads. Thus, the present study confirmed that an increase in plasma sTNFR2 levels is a biomarker for the diagnosis of acute ATL. Examination of plasma sTNFR2 alone or in combination with other ATL biomarkers may be helpful for the diagnosis of acute ATL. |
| first_indexed | 2024-03-09T12:53:02Z |
| format | Article |
| id | doaj.art-8b310b3561604560a1264cd370e20f17 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T12:53:02Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8b310b3561604560a1264cd370e20f172023-11-30T22:03:44ZengMDPI AGViruses1999-49152022-04-0114475110.3390/v14040751Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell LeukemiaMegumi Kato0Naoki Imaizumi1Reiko Tanaka2Mariko Mizuguchi3Masaki Hayashi4Takashi Miyagi5Junnosuke Uchihara6Kazuiku Ohshiro7Junpei Todoroki8Kennosuke Karube9Hiroaki Masuzaki10Yuetsu Tanaka11Takuya Fukushima12Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, JapanLaboratory of Molecular Genetics, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, JapanLaboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, JapanDepartment of Investigative Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, JapanDepartment of Hematology, Nakagami Hospital, Okinawa 904-2142, JapanDepartment of Hematology, Heart Life Hospital, Nakagusuku 901-2492, JapanDepartment of Hematology, Naha City Hospital, Naha 902-8511, JapanDepartment of Hematology, Okinawa Prefectural Nambu Medical Center and Children’s Medical Center, Naha 901-1193, JapanDepartment of Hematology, Chubu Tokushukai Hospital, Nakagami 901-2305, JapanDepartment of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, JapanDivision of Endocrinology, Diabetes, and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, JapanLaboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, JapanLaboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, JapanAdult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for the diagnosis or prediction of the onset of acute ATL, we examined the plasma levels of sTNFR2 in a large number of specimens obtained from a cohort of ATL patients and asymptomatic human T-cell leukemia virus type 1 (HTLV-1) carriers (ACs) and compared them to those of other candidate ATL biomarkers (sCD25, sOX40, and IL-10) by enzyme-linked immunosorbent assays (ELISA) and HTLV-1 proviral loads. We observed that sTNFR2 levels were significantly elevated in acute ATL patients compared to ACs and patients with other types of ATL (chronic, smoldering, and lymphoma). Importantly, sTNFR2 levels were significantly correlated with those of sCD25, sOX40, and IL-10, as well as proviral loads. Thus, the present study confirmed that an increase in plasma sTNFR2 levels is a biomarker for the diagnosis of acute ATL. Examination of plasma sTNFR2 alone or in combination with other ATL biomarkers may be helpful for the diagnosis of acute ATL.https://www.mdpi.com/1999-4915/14/4/751ATLHTLV-1TNFR2OX40CD25IL-10 |
| spellingShingle | Megumi Kato Naoki Imaizumi Reiko Tanaka Mariko Mizuguchi Masaki Hayashi Takashi Miyagi Junnosuke Uchihara Kazuiku Ohshiro Junpei Todoroki Kennosuke Karube Hiroaki Masuzaki Yuetsu Tanaka Takuya Fukushima Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia Viruses ATL HTLV-1 TNFR2 OX40 CD25 IL-10 |
| title | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
| title_full | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
| title_fullStr | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
| title_full_unstemmed | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
| title_short | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
| title_sort | elevation of the plasma levels of tnf receptor 2 in association with those of cd25 ox40 and il 10 and htlv 1 proviral load in acute adult t cell leukemia |
| topic | ATL HTLV-1 TNFR2 OX40 CD25 IL-10 |
| url | https://www.mdpi.com/1999-4915/14/4/751 |
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