A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. I...

Full description

Bibliographic Details
Main Authors: Abigail J Morales, Javier A Carrero, Putzer J Hung, Anthony T Tubbs, Jared M Andrews, Brian T Edelson, Boris Calderon, Cynthia L Innes, Richard S Paules, Jacqueline E Payton, Barry P Sleckman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
macrophage
DNA damage responses
inflammasome
Type I IFN
Online Access:https://elifesciences.org/articles/24655

Internet

https://elifesciences.org/articles/24655

Similar Items