Topical sulindac therapy in diabetic senile cataracts : cataract IV
Sulindac, a non-steroidal anti-inflammatory drug has been found to be a potent inhibitor of enzyme aldose reductase. We used sulindac topically in diabetic senile cataract patients to note if it effects the progression of cataracts. More of sulindac treated eyes maintained initial vision and fewer e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
1989-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=1989;volume=37;issue=3;spage=127;epage=133;aulast=Sharma |
| _version_ | 1819107180546097152 |
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| author | Sharma Y Vajpayee R Bhatnagar R Mohan Madan Azad R Kumar Mukesh Nath Ram |
| author_facet | Sharma Y Vajpayee R Bhatnagar R Mohan Madan Azad R Kumar Mukesh Nath Ram |
| author_sort | Sharma Y |
| collection | DOAJ |
| description | Sulindac, a non-steroidal anti-inflammatory drug has been found to be a potent inhibitor of enzyme aldose reductase. We used sulindac topically in diabetic senile cataract patients to note if it effects the progression of cataracts. More of sulindac treated eyes maintained initial vision and fewer eyes had visual loss of up to two lines or more as compared to control eyes. The extent and density of different opacities showed less progression in sulindac treated eyes but it was not statistically significant except that the ophthalmoscopically observed density of opacity showed statistically very significant lesser mean increase in sulindac treated eyes. We suggest that sulindac is a potential drug which should be further evaluated in large double blind photodocumented studies in diabetic senile cataracts. |
| first_indexed | 2024-12-22T02:49:56Z |
| format | Article |
| id | doaj.art-8b3449e038724e549df5b82004cda612 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 |
| language | English |
| last_indexed | 2024-12-22T02:49:56Z |
| publishDate | 1989-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-8b3449e038724e549df5b82004cda6122022-12-21T18:41:24ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381989-01-01373127133Topical sulindac therapy in diabetic senile cataracts : cataract IVSharma YVajpayee RBhatnagar RMohan MadanAzad RKumar MukeshNath RamSulindac, a non-steroidal anti-inflammatory drug has been found to be a potent inhibitor of enzyme aldose reductase. We used sulindac topically in diabetic senile cataract patients to note if it effects the progression of cataracts. More of sulindac treated eyes maintained initial vision and fewer eyes had visual loss of up to two lines or more as compared to control eyes. The extent and density of different opacities showed less progression in sulindac treated eyes but it was not statistically significant except that the ophthalmoscopically observed density of opacity showed statistically very significant lesser mean increase in sulindac treated eyes. We suggest that sulindac is a potential drug which should be further evaluated in large double blind photodocumented studies in diabetic senile cataracts.http://www.ijo.in/article.asp?issn=0301-4738;year=1989;volume=37;issue=3;spage=127;epage=133;aulast=SharmaSulindacaldose reductasedia-betic senile cataractsprostaglandin pathways |
| spellingShingle | Sharma Y Vajpayee R Bhatnagar R Mohan Madan Azad R Kumar Mukesh Nath Ram Topical sulindac therapy in diabetic senile cataracts : cataract IV Indian Journal of Ophthalmology Sulindac aldose reductase dia-betic senile cataracts prostaglandin pathways |
| title | Topical sulindac therapy in diabetic senile cataracts : cataract IV |
| title_full | Topical sulindac therapy in diabetic senile cataracts : cataract IV |
| title_fullStr | Topical sulindac therapy in diabetic senile cataracts : cataract IV |
| title_full_unstemmed | Topical sulindac therapy in diabetic senile cataracts : cataract IV |
| title_short | Topical sulindac therapy in diabetic senile cataracts : cataract IV |
| title_sort | topical sulindac therapy in diabetic senile cataracts cataract iv |
| topic | Sulindac aldose reductase dia-betic senile cataracts prostaglandin pathways |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=1989;volume=37;issue=3;spage=127;epage=133;aulast=Sharma |
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