Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease
Aim. To evaluate the range of risk factors associated with adverse cardiovascular events onset in hospital period of follow-up in patients with non-ST elevation acute coronary syndrome (NSTEACS) with multivessel disease (MD).Material and methods. To the study, under the framework of prospective, sin...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2018-08-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/606 |
| _version_ | 1797882470484410368 |
|---|---|
| author | Yu. N. Neverova R. S. Tarasov O. A. Nagirnyak |
| author_facet | Yu. N. Neverova R. S. Tarasov O. A. Nagirnyak |
| author_sort | Yu. N. Neverova |
| collection | DOAJ |
| description | Aim. To evaluate the range of risk factors associated with adverse cardiovascular events onset in hospital period of follow-up in patients with non-ST elevation acute coronary syndrome (NSTEACS) with multivessel disease (MD).Material and methods. To the study, under the framework of prospective, single-center registry, the NSTEACS and MD patients were included. Depending on the strategy of revascularization, three groups were selected: staged PCI, coronary bypass (CBG) and PCI as the first with CBG as the second stage. As adverse cardiovascular events, the following were taken: death, myocardial infarction, stroke or transient cerebral ishemia, clinically significant bleeding by BARC, repeat nonscheduled revascularization of target vessel. Results. Analysis revealed the groups of factors increasing the probability of adverse cardiovascular events. Those are: (1) clinical and demographic — older age, diabetes, postinfarction cardiosclerosis, multifocal atherosclerosis, chronic renal failure; (2) coronary and surgical — left main stem lesion, severe atherosclerosis by SYNTAX Score, high surgical risk by EuroScore II, revascularization strategy; (3) predominance of low or moderate risk by GRACE comparing with high risk.Conclusion. The results have confirmed high predictional significance of clinical and demography and coronary factors for development of adverse cardiovascular diseases. A significant finding of the study was the fact that in a hospital with surgery and endovascular treatment available 24/7, the intermediate and low GRACE risk in NSTEACS and MD is a factor of adverse cardiovascular events development due to revascularization delays if the risk is not high. |
| first_indexed | 2024-04-10T03:35:15Z |
| format | Article |
| id | doaj.art-8b34d9a6741a46968f2a577aba96c6b0 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:35:15Z |
| publishDate | 2018-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-8b34d9a6741a46968f2a577aba96c6b02023-03-13T07:23:27Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252018-08-01174192510.15829/1728-8800-2018-4-19-25576Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel diseaseYu. N. Neverova0R. S. Tarasov1O. A. Nagirnyak2ФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийAim. To evaluate the range of risk factors associated with adverse cardiovascular events onset in hospital period of follow-up in patients with non-ST elevation acute coronary syndrome (NSTEACS) with multivessel disease (MD).Material and methods. To the study, under the framework of prospective, single-center registry, the NSTEACS and MD patients were included. Depending on the strategy of revascularization, three groups were selected: staged PCI, coronary bypass (CBG) and PCI as the first with CBG as the second stage. As adverse cardiovascular events, the following were taken: death, myocardial infarction, stroke or transient cerebral ishemia, clinically significant bleeding by BARC, repeat nonscheduled revascularization of target vessel. Results. Analysis revealed the groups of factors increasing the probability of adverse cardiovascular events. Those are: (1) clinical and demographic — older age, diabetes, postinfarction cardiosclerosis, multifocal atherosclerosis, chronic renal failure; (2) coronary and surgical — left main stem lesion, severe atherosclerosis by SYNTAX Score, high surgical risk by EuroScore II, revascularization strategy; (3) predominance of low or moderate risk by GRACE comparing with high risk.Conclusion. The results have confirmed high predictional significance of clinical and demography and coronary factors for development of adverse cardiovascular diseases. A significant finding of the study was the fact that in a hospital with surgery and endovascular treatment available 24/7, the intermediate and low GRACE risk in NSTEACS and MD is a factor of adverse cardiovascular events development due to revascularization delays if the risk is not high.https://cardiovascular.elpub.ru/jour/article/view/606острый коронарный синдром без подъема сегмента st, многососудистое поражение, чрескожное коронарное вмешательствокоронарное шунтированиестратегия реваскуляризациифакторы неблагоприятных исходов |
| spellingShingle | Yu. N. Neverova R. S. Tarasov O. A. Nagirnyak Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease Кардиоваскулярная терапия и профилактика острый коронарный синдром без подъема сегмента st, многососудистое поражение, чрескожное коронарное вмешательство коронарное шунтирование стратегия реваскуляризации факторы неблагоприятных исходов |
| title | Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease |
| title_full | Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease |
| title_fullStr | Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease |
| title_full_unstemmed | Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease |
| title_short | Main predictors of in-hospital adverse outcomes in non-ST elevation acute coronary syndrome patients with multivessel disease |
| title_sort | main predictors of in hospital adverse outcomes in non st elevation acute coronary syndrome patients with multivessel disease |
| topic | острый коронарный синдром без подъема сегмента st, многососудистое поражение, чрескожное коронарное вмешательство коронарное шунтирование стратегия реваскуляризации факторы неблагоприятных исходов |
| url | https://cardiovascular.elpub.ru/jour/article/view/606 |
| work_keys_str_mv | AT yunneverova mainpredictorsofinhospitaladverseoutcomesinnonstelevationacutecoronarysyndromepatientswithmultivesseldisease AT rstarasov mainpredictorsofinhospitaladverseoutcomesinnonstelevationacutecoronarysyndromepatientswithmultivesseldisease AT oanagirnyak mainpredictorsofinhospitaladverseoutcomesinnonstelevationacutecoronarysyndromepatientswithmultivesseldisease |