Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era
The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and high-throughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2006-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752043456X |
| _version_ | 1830191019168104448 |
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| author | Karen Reue Laurent Vergnes |
| author_facet | Karen Reue Laurent Vergnes |
| author_sort | Karen Reue |
| collection | DOAJ |
| description | The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and high-throughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and disease. We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future. |
| first_indexed | 2024-12-17T23:31:05Z |
| format | Article |
| id | doaj.art-8b366d9966204a6d99a306c5a637785b |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T23:31:05Z |
| publishDate | 2006-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-8b366d9966204a6d99a306c5a637785b2022-12-21T21:28:39ZengElsevierJournal of Lipid Research0022-22752006-09-0147918911907Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic eraKaren Reue0Laurent Vergnes1Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095; Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095; Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and high-throughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and disease. We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future.http://www.sciencedirect.com/science/article/pii/S002222752043456Xcomparative genomicspositional cloningfunctional genomicsgene-trap mutagenesisethylnitrosourea mutagenesis |
| spellingShingle | Karen Reue Laurent Vergnes Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era Journal of Lipid Research comparative genomics positional cloning functional genomics gene-trap mutagenesis ethylnitrosourea mutagenesis |
| title | Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era |
| title_full | Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era |
| title_fullStr | Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era |
| title_full_unstemmed | Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era |
| title_short | Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era |
| title_sort | thematic review series systems biology approaches to metabolic and cardiovascular disorders approaches to lipid metabolism gene identification and characterization in the postgenomic era |
| topic | comparative genomics positional cloning functional genomics gene-trap mutagenesis ethylnitrosourea mutagenesis |
| url | http://www.sciencedirect.com/science/article/pii/S002222752043456X |
| work_keys_str_mv | AT karenreue thematicreviewseriessystemsbiologyapproachestometabolicandcardiovasculardisordersapproachestolipidmetabolismgeneidentificationandcharacterizationinthepostgenomicera AT laurentvergnes thematicreviewseriessystemsbiologyapproachestometabolicandcardiovasculardisordersapproachestolipidmetabolismgeneidentificationandcharacterizationinthepostgenomicera |