Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye
We consider the disorders of arousal and sleep-related hypermotor epilepsy as genetic twin-conditions, one without, one with epilepsy. They share an augmented arousal-activity during NREM sleep with sleep-wake dissociations, culminating in sleep terrors and sleep-related hypermotor seizures with sim...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Epilepsy & Behavior Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986424000078 |
| _version_ | 1797281200215162880 |
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| author | Péter Halász Péter Simor Anna Szűcs |
| author_facet | Péter Halász Péter Simor Anna Szűcs |
| author_sort | Péter Halász |
| collection | DOAJ |
| description | We consider the disorders of arousal and sleep-related hypermotor epilepsy as genetic twin-conditions, one without, one with epilepsy. They share an augmented arousal-activity during NREM sleep with sleep-wake dissociations, culminating in sleep terrors and sleep-related hypermotor seizures with similar symptoms. The known mutations underlying the two spectra are different, but there are multifold population-genetic-, family- and even individual (the two conditions occurring in the same person) overlaps supporting common genetic roots. In the episodes of disorders of arousal, the anterior cingulate, anterior insular and pre-frontal cortices (shown to be involved in fear- and emotion processing) are activated within a sleeping brain. These regions overlap with the seizure-onset zones of successfully operated sleep-related hypermotor seizures, and notably, belong to the salience network being consistent with its hubs. The arousal-relatedness and the similar fearful confusion occurring in sleep terrors and hypermotor seizures, make them alike acute stress-responses emerging from sleep; triggered by false alarms. The activation of the anterior cingulate, prefrontal and insular regions in the episodes of both conditions, can easily mobilize the hypothalamo-pituitary-adrenal axis (preparing fight-flight responses in wakefulness); through its direct pathways to and from the salience network. This hypothesis has never been studied. |
| first_indexed | 2024-03-07T16:53:10Z |
| format | Article |
| id | doaj.art-8b3ad471d9d44b2097e4e796c621f7f6 |
| institution | Directory Open Access Journal |
| issn | 2589-9864 |
| language | English |
| last_indexed | 2024-03-07T16:53:10Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj.art-8b3ad471d9d44b2097e4e796c621f7f62024-03-03T04:30:06ZengElsevierEpilepsy & Behavior Reports2589-98642024-01-0125100650Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and SelyePéter Halász0Péter Simor1Anna Szűcs2Szentágothai János Doctoral School, Semmelweis University, Budapest, Hungary; Corresponding author at: 18 Lotz Károly str., 1028 Budapest, Hungary.Institute of Psychology, ELTE Faculty of Education and Psychology, Budapest, HungaryInstitute of Behavioural Sciences Semmelweis University, Budapest, HungaryWe consider the disorders of arousal and sleep-related hypermotor epilepsy as genetic twin-conditions, one without, one with epilepsy. They share an augmented arousal-activity during NREM sleep with sleep-wake dissociations, culminating in sleep terrors and sleep-related hypermotor seizures with similar symptoms. The known mutations underlying the two spectra are different, but there are multifold population-genetic-, family- and even individual (the two conditions occurring in the same person) overlaps supporting common genetic roots. In the episodes of disorders of arousal, the anterior cingulate, anterior insular and pre-frontal cortices (shown to be involved in fear- and emotion processing) are activated within a sleeping brain. These regions overlap with the seizure-onset zones of successfully operated sleep-related hypermotor seizures, and notably, belong to the salience network being consistent with its hubs. The arousal-relatedness and the similar fearful confusion occurring in sleep terrors and hypermotor seizures, make them alike acute stress-responses emerging from sleep; triggered by false alarms. The activation of the anterior cingulate, prefrontal and insular regions in the episodes of both conditions, can easily mobilize the hypothalamo-pituitary-adrenal axis (preparing fight-flight responses in wakefulness); through its direct pathways to and from the salience network. This hypothesis has never been studied.http://www.sciencedirect.com/science/article/pii/S2589986424000078Sleep related hypermotor epilepsySleep terrorSalience networkSham alarm in sleep |
| spellingShingle | Péter Halász Péter Simor Anna Szűcs Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye Epilepsy & Behavior Reports Sleep related hypermotor epilepsy Sleep terror Salience network Sham alarm in sleep |
| title | Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye |
| title_full | Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye |
| title_fullStr | Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye |
| title_full_unstemmed | Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye |
| title_short | Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye |
| title_sort | fearful arousals in sleep terrors and sleep related hypermotor epileptic seizures may involve the salience network and the acute stress response of cannon and selye |
| topic | Sleep related hypermotor epilepsy Sleep terror Salience network Sham alarm in sleep |
| url | http://www.sciencedirect.com/science/article/pii/S2589986424000078 |
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