Chimeric Virus-like Particle-Based COVID-19 Vaccine Confers Strong Protection against SARS-CoV-2 Viremia in K18-hACE2 Mice

Chimeric Virus-like Particle-Based COVID-19 Vaccine Confers Strong Protection against SARS-CoV-2 Viremia in K18-hACE2 Mice

Virus-like particles (VLPs) are highly immunogenic and versatile subunit vaccines composed of multimeric viral proteins that mimic the whole virus but lack genetic material. Due to the lack of infectivity, VLPs are being developed as safe and effective vaccines against various infectious diseases. I...

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Bibliographic Details
Main Authors: Challika Kaewborisuth, Asawin Wanitchang, Surapong Koonpaew, Kanjana Srisutthisamphan, Janya Saenboonrueng, Rawiwan Im-Erbsin, Manutsanun Inthawong, Piyanate Sunyakumthorn, Theeradej Thaweerattanasinp, Nathiphat Tanwattana, Yuparat Jantraphakorn, Matthew C. Reed, Luis A. Lugo-Roman, Taweewun Hunsawong, Chonticha Klungthong, Anthony R. Jones, Stefan Fernandez, Samaporn Teeravechyan, Eric D. Lombardini, Anan Jongkaewwattana
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Vaccines
Subjects:
chimeric virus-like particle
vaccine
SARS-CoV-2
COVID-19
K18-hACE2 mice
Online Access:https://www.mdpi.com/2076-393X/10/5/786

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