Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study
Abstract Background Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) and albuminuria. However, the relationship of specific-domain PA and alb...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05061-6 |
| _version_ | 1797266644697874432 |
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| author | Bingquan Xiong Yufan Wang Juan He Lisha Wang Rui He Min Zhu Jiaxing Wang Yingrui Li Bin Liu Kaihu Xiao Qiang She |
| author_facet | Bingquan Xiong Yufan Wang Juan He Lisha Wang Rui He Min Zhu Jiaxing Wang Yingrui Li Bin Liu Kaihu Xiao Qiang She |
| author_sort | Bingquan Xiong |
| collection | DOAJ |
| description | Abstract Background Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) and albuminuria. However, the relationship of specific-domain PA and albuminuria remained obscure. Methods Albuminuria was defined as urinary albumin/creatinine ratio (ACR) > 30 mg/g. PA was self-reported by participants and classified into transportation-related PA (TPA), occupation-related PA (OPA), and leisure-time PA (LTPA). Weighted logistic regression was conducted to compute the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic spline (RCS) was used to evaluate the dose–response of PA domains with the risk of albuminuria. Results A total of 6739 diabetic/prediabetic patients (mean age: 56.52 ± 0.29 years) were enrolled in our study, including 3181 (47.20%) females and 3558 (52.80%) males. Of them, 1578 (23.42%) were identified with albuminuria, and 5161(76.58%) were without albuminuria. Diabetic/prediabetic patients who adhered the PA guidelines for total PA had a 22% decreased risk of albuminuria (OR = 0.78, 95%CI 0.64–0.95), and those met the PA guidelines for LTPA had a 28% decreased of albuminuria (OR = 0.72, 95%CI 0.57–0.92). However, OPA and TPA were both not associated with decreased risk of albuminuria. RCS showed linear relationship between the risk of albuminuria with LTPA. Conclusions Meeting the PA guideline for LTPA, but not OPA and TPA, was inversely related to the risk of albuminuria among diabetic/prediabetic patients. Additionally, achieving more than 300 min/week of LTPA conferred the positive effects in reducing albuminuria among diabetic/prediabetic patients. |
| first_indexed | 2024-04-25T01:03:58Z |
| format | Article |
| id | doaj.art-8b3ff1a3dbdf4659883df91299c0dca4 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-25T01:03:58Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-8b3ff1a3dbdf4659883df91299c0dca42024-03-10T12:21:01ZengBMCJournal of Translational Medicine1479-58762024-03-0122111310.1186/s12967-024-05061-6Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional studyBingquan Xiong0Yufan Wang1Juan He2Lisha Wang3Rui He4Min Zhu5Jiaxing Wang6Yingrui Li7Bin Liu8Kaihu Xiao9Qiang She10Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiovascular Medicine Intensive Care Unit, The Second Affiliated Hospital of Hainan Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Geriatrics, The First People’s Hospital of NeijiangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract Background Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) and albuminuria. However, the relationship of specific-domain PA and albuminuria remained obscure. Methods Albuminuria was defined as urinary albumin/creatinine ratio (ACR) > 30 mg/g. PA was self-reported by participants and classified into transportation-related PA (TPA), occupation-related PA (OPA), and leisure-time PA (LTPA). Weighted logistic regression was conducted to compute the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic spline (RCS) was used to evaluate the dose–response of PA domains with the risk of albuminuria. Results A total of 6739 diabetic/prediabetic patients (mean age: 56.52 ± 0.29 years) were enrolled in our study, including 3181 (47.20%) females and 3558 (52.80%) males. Of them, 1578 (23.42%) were identified with albuminuria, and 5161(76.58%) were without albuminuria. Diabetic/prediabetic patients who adhered the PA guidelines for total PA had a 22% decreased risk of albuminuria (OR = 0.78, 95%CI 0.64–0.95), and those met the PA guidelines for LTPA had a 28% decreased of albuminuria (OR = 0.72, 95%CI 0.57–0.92). However, OPA and TPA were both not associated with decreased risk of albuminuria. RCS showed linear relationship between the risk of albuminuria with LTPA. Conclusions Meeting the PA guideline for LTPA, but not OPA and TPA, was inversely related to the risk of albuminuria among diabetic/prediabetic patients. Additionally, achieving more than 300 min/week of LTPA conferred the positive effects in reducing albuminuria among diabetic/prediabetic patients.https://doi.org/10.1186/s12967-024-05061-6Physical activityDiabetesAlbuminuriaRiskLifestyle |
| spellingShingle | Bingquan Xiong Yufan Wang Juan He Lisha Wang Rui He Min Zhu Jiaxing Wang Yingrui Li Bin Liu Kaihu Xiao Qiang She Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study Journal of Translational Medicine Physical activity Diabetes Albuminuria Risk Lifestyle |
| title | Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study |
| title_full | Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study |
| title_fullStr | Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study |
| title_full_unstemmed | Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study |
| title_short | Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study |
| title_sort | association of domain specific physical activity with albuminuria among prediabetes and diabetes a large cross sectional study |
| topic | Physical activity Diabetes Albuminuria Risk Lifestyle |
| url | https://doi.org/10.1186/s12967-024-05061-6 |
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