Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis
Evidence has shown the roles of taVNS and TECS in improving depression but few studies have explored their synergistic effects on MDD. Therefore, the treatment responsivity and neurological effects of TECAS were investigated and compared to escitalopram, a commonly used medication for depression. Fi...
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MDPI AG
2023-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/2/274 |
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| author | Lifang Liao Liulu Zhang Jun Lv Yingchun Liu Jiliang Fang Peijing Rong Yong Liu |
| author_facet | Lifang Liao Liulu Zhang Jun Lv Yingchun Liu Jiliang Fang Peijing Rong Yong Liu |
| author_sort | Lifang Liao |
| collection | DOAJ |
| description | Evidence has shown the roles of taVNS and TECS in improving depression but few studies have explored their synergistic effects on MDD. Therefore, the treatment responsivity and neurological effects of TECAS were investigated and compared to escitalopram, a commonly used medication for depression. Fifty patients with mild-to-moderate MDD (29 in the TECAS group and 21 in another) and 49 demographically matched healthy controls were recruited. After an eight-week treatment, the outcomes of TECAS and escitalopram were evaluated by the effective rate and reduction rate based on the Montgomery–Asberg Depression Rating Scale, Hamilton Depression Rating Scale, and Hamilton Anxiety Rating Scale. Altered brain networks were analyzed between pre- and post-treatment using independent component analysis. There was no significant difference in clinical scales between TECAS and escitalopram but these were significantly decreased after each treatment. Both treatments modulated connectivity of the default mode network (DMN), dorsal attention network (DAN), right frontoparietal network (RFPN), and primary visual network (PVN), and the decreased PVN–RFPN connectivity might be the common brain mechanism. However, there was increased DMN–RFPN and DMN–DAN connectivity after TECAS, while it decreased in escitalopram. In conclusion, TECAS could relieve symptoms of depression similarly to escitalopram but induces different changes in brain networks. |
| first_indexed | 2024-03-11T09:05:07Z |
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| id | doaj.art-8b40666521ce490fa6aa6bf15ca24e39 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T09:05:07Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-8b40666521ce490fa6aa6bf15ca24e392023-11-16T19:28:41ZengMDPI AGBrain Sciences2076-34252023-02-0113227410.3390/brainsci13020274Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component AnalysisLifang Liao0Liulu Zhang1Jun Lv2Yingchun Liu3Jiliang Fang4Peijing Rong5Yong Liu6College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, ChinaDepartment of Magnetic Resonance Imaging, Affiliated Chinese Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, ChinaDepartment of Comprehensive Internal Medicine, Affiliated Chinese Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, ChinaDepartment of Magnetic Resonance Imaging, Affiliated Chinese Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100005, ChinaDepartment of Magnetic Resonance Imaging, Affiliated Chinese Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, ChinaEvidence has shown the roles of taVNS and TECS in improving depression but few studies have explored their synergistic effects on MDD. Therefore, the treatment responsivity and neurological effects of TECAS were investigated and compared to escitalopram, a commonly used medication for depression. Fifty patients with mild-to-moderate MDD (29 in the TECAS group and 21 in another) and 49 demographically matched healthy controls were recruited. After an eight-week treatment, the outcomes of TECAS and escitalopram were evaluated by the effective rate and reduction rate based on the Montgomery–Asberg Depression Rating Scale, Hamilton Depression Rating Scale, and Hamilton Anxiety Rating Scale. Altered brain networks were analyzed between pre- and post-treatment using independent component analysis. There was no significant difference in clinical scales between TECAS and escitalopram but these were significantly decreased after each treatment. Both treatments modulated connectivity of the default mode network (DMN), dorsal attention network (DAN), right frontoparietal network (RFPN), and primary visual network (PVN), and the decreased PVN–RFPN connectivity might be the common brain mechanism. However, there was increased DMN–RFPN and DMN–DAN connectivity after TECAS, while it decreased in escitalopram. In conclusion, TECAS could relieve symptoms of depression similarly to escitalopram but induces different changes in brain networks.https://www.mdpi.com/2076-3425/13/2/274depressiontranscutaneous electrical cranial-auricular acupoint stimulation (TECAS)escitalopramresting-state functional magnetic resonance imagingMRIindependent component analysis (ICA) |
| spellingShingle | Lifang Liao Liulu Zhang Jun Lv Yingchun Liu Jiliang Fang Peijing Rong Yong Liu Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis Brain Sciences depression transcutaneous electrical cranial-auricular acupoint stimulation (TECAS) escitalopram resting-state functional magnetic resonance imaging MRI independent component analysis (ICA) |
| title | Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis |
| title_full | Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis |
| title_fullStr | Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis |
| title_full_unstemmed | Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis |
| title_short | Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation Modulating the Brain Functional Connectivity of Mild-to-Moderate Major Depressive Disorder: An fMRI Study Based on Independent Component Analysis |
| title_sort | transcutaneous electrical cranial auricular acupoint stimulation modulating the brain functional connectivity of mild to moderate major depressive disorder an fmri study based on independent component analysis |
| topic | depression transcutaneous electrical cranial-auricular acupoint stimulation (TECAS) escitalopram resting-state functional magnetic resonance imaging MRI independent component analysis (ICA) |
| url | https://www.mdpi.com/2076-3425/13/2/274 |
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