Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis
Objectives This review aimed at identifying the elements of integrated care models for cardiometabolic multimorbidity in sub-Saharan Africa (SSA) and their effects on clinical or mental health outcomes including systolic blood pressure (SBP), blood sugar, depression scores and other patient-reported...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/6/e073652.full |
| _version_ | 1797746125280641024 |
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| author | Charles Agyemang Gershim Asiki Daniel Mwanga Peter Kibe Hesborn Wao Peter Otieno Elvis Wambiya Maurine Ng’oda James Oguta |
| author_facet | Charles Agyemang Gershim Asiki Daniel Mwanga Peter Kibe Hesborn Wao Peter Otieno Elvis Wambiya Maurine Ng’oda James Oguta |
| author_sort | Charles Agyemang |
| collection | DOAJ |
| description | Objectives This review aimed at identifying the elements of integrated care models for cardiometabolic multimorbidity in sub-Saharan Africa (SSA) and their effects on clinical or mental health outcomes including systolic blood pressure (SBP), blood sugar, depression scores and other patient-reported outcomes such as quality of life and medication adherence.Design Systematic review and meta-analysis using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach.Data sources We systematically searched PubMed, Embase, Scopus, Web of Science, Global Health CINAHL, African Journals Online, Informit, PsycINFO, ClinicalTrials.gov, Pan African Clinical Trials Registry and grey literature from OpenSIGLE for studies published between 1999 and 2022.Eligibility criteria for selecting studies We included randomised controlled trial studies featuring integrated care models with two or more elements of Wagner’s chronic care model.Data extraction and synthesis Two independent reviewers used standardised methods to search and screen included studies. Publication bias was assessed using the Doi plot and Luis Furuya Kanamori Index. Meta-analysis was conducted using random effects models.Results In all, we included 10 randomised controlled trials from 11 publications with 4864 participants from six SSA countries (South Africa, Kenya, Nigeria, Eswatini, Ghana and Uganda). The overall quality of evidence based on GRADE criteria was moderate. A random-effects meta-analysis of six studies involving 1754 participants shows that integrated compared with standard care conferred a moderately lower mean SBP (mean difference=−4.85 mm Hg, 95% CI −7.37 to −2.34) for people with cardiometabolic multimorbidity; Hedges’ g effect size (g=−0.25, (−0.39 to −0.11). However, integrated care compared with usual care showed mixed results for glycated haemoglobin, depression, medication adherence and quality of life.Conclusion Integrated care improved SBP among patients living with cardiometabolic multimorbidity in SSA. More studies on integrated care are required to improve the evidence pool on chronic care models for multimorbidity in SSA. These include implementation studies and cost-effectiveness studies.PROSPERO registration number CRD42020187756. |
| first_indexed | 2024-03-12T15:32:36Z |
| format | Article |
| id | doaj.art-8b40a579256f4c4ea301a86d4a3eb5b5 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T15:32:36Z |
| publishDate | 2023-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-8b40a579256f4c4ea301a86d4a3eb5b52023-08-09T22:25:07ZengBMJ Publishing GroupBMJ Open2044-60552023-06-0113610.1136/bmjopen-2023-073652Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysisCharles Agyemang0Gershim Asiki1Daniel Mwanga2Peter Kibe3Hesborn Wao4Peter Otieno5Elvis Wambiya6Maurine Ng’oda7James Oguta82 Department of Public & Occupational Health, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands1 Chronic Disease Management Unit, African Population and Health Research Center, Nairobi, Kenya3 Data Science and Evaluation, African Population and Health Research Center, Nairobi, Kenya1 Chronic Disease Management Unit, African Population and Health Research Center, Nairobi, Kenya4 Research and Related Capacity Strengthening, African Population and Health Research Center, Nairobi, Kenya1 Chronic Disease Management Unit, African Population and Health Research Center, Nairobi, Kenya5 School of Health and Related Research, The University of Sheffield, Sheffield, UK7 Emerging and Re-emerging infectious Diseases Unit, African Population and Health Research Center, Nairobi, Kenya5 School of Health and Related Research, The University of Sheffield, Sheffield, UKObjectives This review aimed at identifying the elements of integrated care models for cardiometabolic multimorbidity in sub-Saharan Africa (SSA) and their effects on clinical or mental health outcomes including systolic blood pressure (SBP), blood sugar, depression scores and other patient-reported outcomes such as quality of life and medication adherence.Design Systematic review and meta-analysis using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach.Data sources We systematically searched PubMed, Embase, Scopus, Web of Science, Global Health CINAHL, African Journals Online, Informit, PsycINFO, ClinicalTrials.gov, Pan African Clinical Trials Registry and grey literature from OpenSIGLE for studies published between 1999 and 2022.Eligibility criteria for selecting studies We included randomised controlled trial studies featuring integrated care models with two or more elements of Wagner’s chronic care model.Data extraction and synthesis Two independent reviewers used standardised methods to search and screen included studies. Publication bias was assessed using the Doi plot and Luis Furuya Kanamori Index. Meta-analysis was conducted using random effects models.Results In all, we included 10 randomised controlled trials from 11 publications with 4864 participants from six SSA countries (South Africa, Kenya, Nigeria, Eswatini, Ghana and Uganda). The overall quality of evidence based on GRADE criteria was moderate. A random-effects meta-analysis of six studies involving 1754 participants shows that integrated compared with standard care conferred a moderately lower mean SBP (mean difference=−4.85 mm Hg, 95% CI −7.37 to −2.34) for people with cardiometabolic multimorbidity; Hedges’ g effect size (g=−0.25, (−0.39 to −0.11). However, integrated care compared with usual care showed mixed results for glycated haemoglobin, depression, medication adherence and quality of life.Conclusion Integrated care improved SBP among patients living with cardiometabolic multimorbidity in SSA. More studies on integrated care are required to improve the evidence pool on chronic care models for multimorbidity in SSA. These include implementation studies and cost-effectiveness studies.PROSPERO registration number CRD42020187756.https://bmjopen.bmj.com/content/13/6/e073652.full |
| spellingShingle | Charles Agyemang Gershim Asiki Daniel Mwanga Peter Kibe Hesborn Wao Peter Otieno Elvis Wambiya Maurine Ng’oda James Oguta Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis BMJ Open |
| title | Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis |
| title_full | Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis |
| title_fullStr | Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis |
| title_full_unstemmed | Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis |
| title_short | Effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub-Saharan Africa: a systematic review and meta-analysis |
| title_sort | effectiveness of integrated chronic care models for cardiometabolic multimorbidity in sub saharan africa a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/13/6/e073652.full |
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