New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local inflammation. Immune and inflammatory responses have significant effects on every phase of atherosclerosis, and increasing ev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/18/10/2034 |
| _version_ | 1811231736331239424 |
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| author | Meng-Yu Wu Chia-Jung Li Ming-Feng Hou Pei-Yi Chu |
| author_facet | Meng-Yu Wu Chia-Jung Li Ming-Feng Hou Pei-Yi Chu |
| author_sort | Meng-Yu Wu |
| collection | DOAJ |
| description | Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local inflammation. Immune and inflammatory responses have significant effects on every phase of atherosclerosis, and increasing evidence shows that immunity plays a more important role in atherosclerosis by tightly regulating its progression. Therefore, understanding the relationship between immune responses and the atherosclerotic microenvironment is extremely important. This article reviews existing knowledge regarding the pathogenesis of immune responses in the atherosclerotic microenvironment, and the immune mechanisms involved in atherosclerosis formation and activation. |
| first_indexed | 2024-04-12T10:51:10Z |
| format | Article |
| id | doaj.art-8b40d29fbb3d488ba91f146aee1f8b77 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T10:51:10Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8b40d29fbb3d488ba91f146aee1f8b772022-12-22T03:36:15ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-09-011810203410.3390/ijms18102034ijms18102034New Insights into the Role of Inflammation in the Pathogenesis of AtherosclerosisMeng-Yu Wu0Chia-Jung Li1Ming-Feng Hou2Pei-Yi Chu3Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, TaiwanResearch Assistant Center, Show Chwan Memorial Hospital, Changhua 500, TaiwanDepartment of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Pathology, Show Chwan Memorial Hospital, Changhua 500, TaiwanAtherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local inflammation. Immune and inflammatory responses have significant effects on every phase of atherosclerosis, and increasing evidence shows that immunity plays a more important role in atherosclerosis by tightly regulating its progression. Therefore, understanding the relationship between immune responses and the atherosclerotic microenvironment is extremely important. This article reviews existing knowledge regarding the pathogenesis of immune responses in the atherosclerotic microenvironment, and the immune mechanisms involved in atherosclerosis formation and activation.https://www.mdpi.com/1422-0067/18/10/2034atherosclerosisatherosclerotic immunityatherosclerotic microenvironmentoxidative stressmacrophage |
| spellingShingle | Meng-Yu Wu Chia-Jung Li Ming-Feng Hou Pei-Yi Chu New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis International Journal of Molecular Sciences atherosclerosis atherosclerotic immunity atherosclerotic microenvironment oxidative stress macrophage |
| title | New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis |
| title_full | New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis |
| title_fullStr | New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis |
| title_full_unstemmed | New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis |
| title_short | New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis |
| title_sort | new insights into the role of inflammation in the pathogenesis of atherosclerosis |
| topic | atherosclerosis atherosclerotic immunity atherosclerotic microenvironment oxidative stress macrophage |
| url | https://www.mdpi.com/1422-0067/18/10/2034 |
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