ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension
Background: Hypertension has a multifactorial background based on genetic and environmental interactive factors. Objectives: We aimed to test for the association of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) gene polymorphisms with hypertension. Subjects and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2013-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312459976 |
| _version_ | 1797285741115473920 |
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| author | Ahmad Ali Abdullah Alghasham Hisham Ismail Moataz Dowaidar Ahmad Settin |
| author_facet | Ahmad Ali Abdullah Alghasham Hisham Ismail Moataz Dowaidar Ahmad Settin |
| author_sort | Ahmad Ali |
| collection | DOAJ |
| description | Background: Hypertension has a multifactorial background based on genetic and environmental interactive factors. Objectives: We aimed to test for the association of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) gene polymorphisms with hypertension. Subjects and methods: Participants included 120 Saudi patients with hypertension and 250 normal healthy controls. For all participants, DNA was processed for characterization of ACE I/D and eNOS E298D gene polymorphisms. Results: Hypertensive cases showed a significantly higher frequency of the ACE mutant D allele carriage (98.3% vs. 92.4%, p = 0.028, OR = 4.8). Cases with hypertension associated with diabetes and obesity showed 100% mutant D allele carriage. Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05). Conclusions: There is increased frequency of ACE and eNOS mutant allele carriage among Saudi patients affected with hypertension, particularly if accompanied by obesity and diabetes. |
| first_indexed | 2024-03-07T18:07:37Z |
| format | Article |
| id | doaj.art-8b411ecd100743299fe522abbef65623 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:07:37Z |
| publishDate | 2013-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-8b411ecd100743299fe522abbef656232024-03-02T08:32:50ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762013-12-011410.1177/1470320312459976ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertensionAhmad Ali0Abdullah Alghasham1Hisham Ismail2Moataz Dowaidar3Ahmad Settin4Molecular Biology Research Center, College of Medicine, Qassim University, Burayda, Saudi ArabiaDepartment of Pharmacology, College of Medicine, Qassim University, Burayda, Saudi ArabiaClinical Pathology Department, College of Medicine, Qassim University, Burayda, Saudi ArabiaMolecular Biology Research Center, College of Medicine, Qassim University, Burayda, Saudi ArabiaMolecular Biology Research Center, College of Medicine, Qassim University, Burayda, Saudi ArabiaBackground: Hypertension has a multifactorial background based on genetic and environmental interactive factors. Objectives: We aimed to test for the association of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) gene polymorphisms with hypertension. Subjects and methods: Participants included 120 Saudi patients with hypertension and 250 normal healthy controls. For all participants, DNA was processed for characterization of ACE I/D and eNOS E298D gene polymorphisms. Results: Hypertensive cases showed a significantly higher frequency of the ACE mutant D allele carriage (98.3% vs. 92.4%, p = 0.028, OR = 4.8). Cases with hypertension associated with diabetes and obesity showed 100% mutant D allele carriage. Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05). Conclusions: There is increased frequency of ACE and eNOS mutant allele carriage among Saudi patients affected with hypertension, particularly if accompanied by obesity and diabetes.https://doi.org/10.1177/1470320312459976 |
| spellingShingle | Ahmad Ali Abdullah Alghasham Hisham Ismail Moataz Dowaidar Ahmad Settin ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension Journal of the Renin-Angiotensin-Aldosterone System |
| title | ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension |
| title_full | ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension |
| title_fullStr | ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension |
| title_full_unstemmed | ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension |
| title_short | ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension |
| title_sort | ace i d and enos e298d gene polymorphisms in saudi subjects with hypertension |
| url | https://doi.org/10.1177/1470320312459976 |
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