Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure
Fat accumulation in skeletal muscle was recently established as a major risk factor for cardiovascular disease (CVD) in the general population, but its relevance for patients with kidney failure is unknown. Here we examined the potential association between muscle radiation attenuation (MRA), a non-...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00130/full |
| _version_ | 1819226214074679296 |
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| author | Mehdi Keddar Mehdi Keddar Thibaut Muylle Thibaut Muylle Emmanuelle Carrie Emmanuelle Carrie Pierre Trefois Maxime Nachit Maxime Nachit Ralph Crott Claudine Christiaens Bert Bammens Bert Bammens Michel Jadoul Michel Jadoul Eric Goffin Eric Goffin Johann Morelle Johann Morelle |
| author_facet | Mehdi Keddar Mehdi Keddar Thibaut Muylle Thibaut Muylle Emmanuelle Carrie Emmanuelle Carrie Pierre Trefois Maxime Nachit Maxime Nachit Ralph Crott Claudine Christiaens Bert Bammens Bert Bammens Michel Jadoul Michel Jadoul Eric Goffin Eric Goffin Johann Morelle Johann Morelle |
| author_sort | Mehdi Keddar |
| collection | DOAJ |
| description | Fat accumulation in skeletal muscle was recently established as a major risk factor for cardiovascular disease (CVD) in the general population, but its relevance for patients with kidney failure is unknown. Here we examined the potential association between muscle radiation attenuation (MRA), a non-invasive indicator of fat deposits in muscle, and cardiovascular events in patients with kidney failure treated with peritoneal dialysis (PD) and investigated dynamic changes and determinants of MRA in this population. We retrospectively assessed MRA on computed tomography images collected yearly in 101 incident patients with kidney failure starting PD between January 2006 and December 2015. After a median of 21 months on dialysis, 34 patients had 58 non-fatal cardiovascular events, and 22 patients had died. Baseline MRA was associated with cardiovascular events during time on dialysis, and patients with higher MRA (reflecting lower amounts of fat in muscle) showed a reduced incidence of CVD, independently of traditional risk factors (adjusted HR, 0.91; 95% CI, 0.86–0.97, P = 0.006). Multivariate regression analysis identified old age, female gender, visceral fat area, and low residual urine volume as independent determinants of MRA. As compared with reference values from a healthy population, patients with kidney failure had lower MRA (i.e., increased fat accumulation), independently of age, gender, and body-mass index. The subset of patients who underwent kidney transplantation showed a significant increase in MRA after restoration of kidney function. These observations expand the association between ectopic fat accumulation and CVD to the population on dialysis, and suggest that kidney failure is reversibly associated with fatty muscle infiltration. |
| first_indexed | 2024-12-23T10:21:56Z |
| format | Article |
| id | doaj.art-8b42ad51839e4d8ba3ba54937084295f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T10:21:56Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8b42ad51839e4d8ba3ba54937084295f2022-12-21T17:50:40ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-02-011110.3389/fphys.2020.00130514577Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney FailureMehdi Keddar0Mehdi Keddar1Thibaut Muylle2Thibaut Muylle3Emmanuelle Carrie4Emmanuelle Carrie5Pierre Trefois6Maxime Nachit7Maxime Nachit8Ralph Crott9Claudine Christiaens10Bert Bammens11Bert Bammens12Michel Jadoul13Michel Jadoul14Eric Goffin15Eric Goffin16Johann Morelle17Johann Morelle18Division of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumDepartment of Medical Imaging, Cliniques Universitaires Saint-Luc, Brussels, BelgiumDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumDepartment of Medical Imaging, Cliniques Universitaires Saint-Luc, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumDepartment of Imaging and Pathology, KU Leuven, Leuven, BelgiumConsultant, Colombiers, FranceDepartment of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, BelgiumDepartment of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, BelgiumDepartment of Microbiology and Immunology, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, BelgiumDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, BelgiumFat accumulation in skeletal muscle was recently established as a major risk factor for cardiovascular disease (CVD) in the general population, but its relevance for patients with kidney failure is unknown. Here we examined the potential association between muscle radiation attenuation (MRA), a non-invasive indicator of fat deposits in muscle, and cardiovascular events in patients with kidney failure treated with peritoneal dialysis (PD) and investigated dynamic changes and determinants of MRA in this population. We retrospectively assessed MRA on computed tomography images collected yearly in 101 incident patients with kidney failure starting PD between January 2006 and December 2015. After a median of 21 months on dialysis, 34 patients had 58 non-fatal cardiovascular events, and 22 patients had died. Baseline MRA was associated with cardiovascular events during time on dialysis, and patients with higher MRA (reflecting lower amounts of fat in muscle) showed a reduced incidence of CVD, independently of traditional risk factors (adjusted HR, 0.91; 95% CI, 0.86–0.97, P = 0.006). Multivariate regression analysis identified old age, female gender, visceral fat area, and low residual urine volume as independent determinants of MRA. As compared with reference values from a healthy population, patients with kidney failure had lower MRA (i.e., increased fat accumulation), independently of age, gender, and body-mass index. The subset of patients who underwent kidney transplantation showed a significant increase in MRA after restoration of kidney function. These observations expand the association between ectopic fat accumulation and CVD to the population on dialysis, and suggest that kidney failure is reversibly associated with fatty muscle infiltration.https://www.frontiersin.org/article/10.3389/fphys.2020.00130/fullcardiovascular diseasemyosteatosischronic kidney diseaseend-stage kidney diseaseperitoneal dialysis |
| spellingShingle | Mehdi Keddar Mehdi Keddar Thibaut Muylle Thibaut Muylle Emmanuelle Carrie Emmanuelle Carrie Pierre Trefois Maxime Nachit Maxime Nachit Ralph Crott Claudine Christiaens Bert Bammens Bert Bammens Michel Jadoul Michel Jadoul Eric Goffin Eric Goffin Johann Morelle Johann Morelle Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure Frontiers in Physiology cardiovascular disease myosteatosis chronic kidney disease end-stage kidney disease peritoneal dialysis |
| title | Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure |
| title_full | Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure |
| title_fullStr | Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure |
| title_full_unstemmed | Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure |
| title_short | Non-invasive Quantification of Fat Deposits in Skeletal Muscle Predicts Cardiovascular Outcome in Kidney Failure |
| title_sort | non invasive quantification of fat deposits in skeletal muscle predicts cardiovascular outcome in kidney failure |
| topic | cardiovascular disease myosteatosis chronic kidney disease end-stage kidney disease peritoneal dialysis |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00130/full |
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