The relation between the blood osteopontin levels and body fat percentage in asthmatic women
Introduction: Obesity and asthma prevalence have been increasing over the past decade. Osteopontin (OPN) is a cytokine, with suggested diverse roles in tissue remodeling, fibrosis, immunomodulation, inflammation, and tumor metastasis. Aim of the work: To assess the relation between serum osteopontin...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763813002471 |
| _version_ | 1811262852068016128 |
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| author | Enas E. Mohamed Doaa M. Samy Nesrine M. El Azhary Hanan M. Nomeir |
| author_facet | Enas E. Mohamed Doaa M. Samy Nesrine M. El Azhary Hanan M. Nomeir |
| author_sort | Enas E. Mohamed |
| collection | DOAJ |
| description | Introduction: Obesity and asthma prevalence have been increasing over the past decade. Osteopontin (OPN) is a cytokine, with suggested diverse roles in tissue remodeling, fibrosis, immunomodulation, inflammation, and tumor metastasis.
Aim of the work: To assess the relation between serum osteopontin, immunoglobulin E (IgE) and body fat percentage in obese and non-obese asthmatic women in addition, to determine whether correlations exist between these parameters and asthma control.
Patients and methods: This study was conducted on 40 women after taking informed written consents. They were divided into 4 groups (10 each): healthy non-obese non-asthmatic (NO/NA), obese non-asthmatic (O/NA), non-obese asthmatic (NO/A) and obese asthmatic (O/A). All were subjected to full history taking, spirometry to non-asthmatic, asthma control questionnaire (ACQ) to asthmatic, determination of body fat percentage and serum levels of osteopontin and IgE.
Results: Body fat percentage was positively correlated to serum OPN levels. Body fat percentage was positively correlated to concentrations of IgE. In addition, the correlation between serum OPN levels and serum IgE levels was significantly positive. The improvement (presented by difference between ACQ before and after treatment (Δ ACQ)) was significantly superior in non-obese asthmatic. A negative correlation was detected between Δ ACQ and body fat percentage, serum OPN and IgE concentration.
In conclusion: Because the multiple roles of OPN action potentially contribute to inflammation in obesity, it is suggested that, in addition to weight reduction, interference with OPN action could become a therapeutic strategy in the treatment of obesity worsening disorders like bronchial asthma. |
| first_indexed | 2024-04-12T19:34:24Z |
| format | Article |
| id | doaj.art-8b43790b6cc24e19a25861d73c0f9a25 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-04-12T19:34:24Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-8b43790b6cc24e19a25861d73c0f9a252022-12-22T03:19:15ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382014-01-01631879710.1016/j.ejcdt.2013.10.010The relation between the blood osteopontin levels and body fat percentage in asthmatic womenEnas E. Mohamed0Doaa M. Samy1Nesrine M. El Azhary2Hanan M. Nomeir3Chest Diseases Department, Faculty of Medicine, Alexandria University, EgyptPhysiology Department, Faculty of Medicine, Alexandria University, EgyptPhysiology Department, Faculty of Medicine, Alexandria University, EgyptMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Alexandria University, EgyptIntroduction: Obesity and asthma prevalence have been increasing over the past decade. Osteopontin (OPN) is a cytokine, with suggested diverse roles in tissue remodeling, fibrosis, immunomodulation, inflammation, and tumor metastasis. Aim of the work: To assess the relation between serum osteopontin, immunoglobulin E (IgE) and body fat percentage in obese and non-obese asthmatic women in addition, to determine whether correlations exist between these parameters and asthma control. Patients and methods: This study was conducted on 40 women after taking informed written consents. They were divided into 4 groups (10 each): healthy non-obese non-asthmatic (NO/NA), obese non-asthmatic (O/NA), non-obese asthmatic (NO/A) and obese asthmatic (O/A). All were subjected to full history taking, spirometry to non-asthmatic, asthma control questionnaire (ACQ) to asthmatic, determination of body fat percentage and serum levels of osteopontin and IgE. Results: Body fat percentage was positively correlated to serum OPN levels. Body fat percentage was positively correlated to concentrations of IgE. In addition, the correlation between serum OPN levels and serum IgE levels was significantly positive. The improvement (presented by difference between ACQ before and after treatment (Δ ACQ)) was significantly superior in non-obese asthmatic. A negative correlation was detected between Δ ACQ and body fat percentage, serum OPN and IgE concentration. In conclusion: Because the multiple roles of OPN action potentially contribute to inflammation in obesity, it is suggested that, in addition to weight reduction, interference with OPN action could become a therapeutic strategy in the treatment of obesity worsening disorders like bronchial asthma.http://www.sciencedirect.com/science/article/pii/S0422763813002471ObesityOsteopontinBody fat percentageImmunoglobulin E |
| spellingShingle | Enas E. Mohamed Doaa M. Samy Nesrine M. El Azhary Hanan M. Nomeir The relation between the blood osteopontin levels and body fat percentage in asthmatic women Egyptian Journal of Chest Disease and Tuberculosis Obesity Osteopontin Body fat percentage Immunoglobulin E |
| title | The relation between the blood osteopontin levels and body fat percentage in asthmatic women |
| title_full | The relation between the blood osteopontin levels and body fat percentage in asthmatic women |
| title_fullStr | The relation between the blood osteopontin levels and body fat percentage in asthmatic women |
| title_full_unstemmed | The relation between the blood osteopontin levels and body fat percentage in asthmatic women |
| title_short | The relation between the blood osteopontin levels and body fat percentage in asthmatic women |
| title_sort | relation between the blood osteopontin levels and body fat percentage in asthmatic women |
| topic | Obesity Osteopontin Body fat percentage Immunoglobulin E |
| url | http://www.sciencedirect.com/science/article/pii/S0422763813002471 |
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