Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease
Ferroptosis is a new type of cell death proposed in recent years, and its main characteristics are iron overload and lipid peroxidation. Ferroptosis is involved in the occurrence and development of non-alcoholic fatty liver disease(NAFLD). Iron overload can generate a large amount of reactive oxygen...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-02-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-2-260.pdf |
| _version_ | 1827373727626559488 |
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| author | XIAO Yanxin, LIU Yan, XU Lingling, ZHOU Yaru |
| author_facet | XIAO Yanxin, LIU Yan, XU Lingling, ZHOU Yaru |
| author_sort | XIAO Yanxin, LIU Yan, XU Lingling, ZHOU Yaru |
| collection | DOAJ |
| description | Ferroptosis is a new type of cell death proposed in recent years, and its main characteristics are iron overload and lipid peroxidation. Ferroptosis is involved in the occurrence and development of non-alcoholic fatty liver disease(NAFLD). Iron overload can generate a large amount of reactive oxygen species through the Fenton reaction. Under the action of lipoxygenase, the unsaturated fatty acids on the liver cell membrane undergo lipid peroxidation, which induces liver cell death and leads to the occurrence of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. Blocking ferroptosis may provide one of the therapeutic strategies to protect liver cells. |
| first_indexed | 2024-03-08T11:21:34Z |
| format | Article |
| id | doaj.art-8b4426cc6199482c9451a8caba999425 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T11:21:34Z |
| publishDate | 2024-02-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-8b4426cc6199482c9451a8caba9994252024-01-26T09:27:35ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-02-0144226026410.16352/j.issn.1001-6325.2024.02.0260Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver diseaseXIAO Yanxin, LIU Yan, XU Lingling, ZHOU Yaru01. Department of Endocrinology,Baoding NO.1 Central Hospital, Baoding 071000; ;2. Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051; ;3. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, ChinaFerroptosis is a new type of cell death proposed in recent years, and its main characteristics are iron overload and lipid peroxidation. Ferroptosis is involved in the occurrence and development of non-alcoholic fatty liver disease(NAFLD). Iron overload can generate a large amount of reactive oxygen species through the Fenton reaction. Under the action of lipoxygenase, the unsaturated fatty acids on the liver cell membrane undergo lipid peroxidation, which induces liver cell death and leads to the occurrence of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. Blocking ferroptosis may provide one of the therapeutic strategies to protect liver cells.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-2-260.pdfferroptosis|non-alcoholic fatty liver disease|lipid peroxidation|iron overload |
| spellingShingle | XIAO Yanxin, LIU Yan, XU Lingling, ZHOU Yaru Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease Jichu yixue yu linchuang ferroptosis|non-alcoholic fatty liver disease|lipid peroxidation|iron overload |
| title | Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease |
| title_full | Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease |
| title_fullStr | Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease |
| title_full_unstemmed | Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease |
| title_short | Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease |
| title_sort | research progress on the role of ferroptosis in the pathogenesis of non alcoholic fatty liver disease |
| topic | ferroptosis|non-alcoholic fatty liver disease|lipid peroxidation|iron overload |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-2-260.pdf |
| work_keys_str_mv | AT xiaoyanxinliuyanxulinglingzhouyaru researchprogressontheroleofferroptosisinthepathogenesisofnonalcoholicfattyliverdisease |