Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Abstract Histologically, melanoma tissues had fewer positive cells percentage of pyroptosis-related genes (PRGs), GZMA, GSDMB, NLRP1, IL18, and CHMP4A in epidermal than in normal skin. Pyroptosis, a new frontier in cancer, affects the tumor microenvironment and tumor immunotherapy. Nevertheless, the...

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Bibliographic Details
Main Authors: Ying Zhang, Yun Bai, Xiao-Xuan Ma, Jian-Kun Song, Yue Luo, Xiao-Ya Fei, Yi Ru, Ying Luo, Jing-Si Jiang, Zhan Zhang, Dan Yang, Ting-Ting Xue, Hui-Ping Zhang, Tai-Yi Liu, Yan-Wei Xiang, Le Kuai, Ye-Qiang Liu, Bin Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06068-5

Internet

https://doi.org/10.1038/s41419-023-06068-5

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