Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence
Abstract Histologically, melanoma tissues had fewer positive cells percentage of pyroptosis-related genes (PRGs), GZMA, GSDMB, NLRP1, IL18, and CHMP4A in epidermal than in normal skin. Pyroptosis, a new frontier in cancer, affects the tumor microenvironment and tumor immunotherapy. Nevertheless, the...
Main Authors: | Ying Zhang, Yun Bai, Xiao-Xuan Ma, Jian-Kun Song, Yue Luo, Xiao-Ya Fei, Yi Ru, Ying Luo, Jing-Si Jiang, Zhan Zhang, Dan Yang, Ting-Ting Xue, Hui-Ping Zhang, Tai-Yi Liu, Yan-Wei Xiang, Le Kuai, Ye-Qiang Liu, Bin Li |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-08-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-023-06068-5 |
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