Pan-Cancer Analysis Shows <i>TP53</i> Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome

Pan-Cancer Analysis Shows <i>TP53</i> Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome

Previously, we have shown TGF-β-induced NOX4 expression is involved in the epithelial-to-mesenchymal transition (EMT), a process critical for cancer metastasis, and that wild-type (WT) and mutant (Mut) p53 have divergent effects on TGF-β induction of NOX4: WT-p53 suppresses whereas Mut-p53 augments...

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Bibliographic Details
Main Authors: Wei Feng Ma, Howard E. Boudreau, Thomas L. Leto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antioxidants
Subjects:
NOX4
NADPH oxidase
EMT
p53
TCGA
bioinformatics
Online Access:https://www.mdpi.com/2076-3921/10/2/235

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