Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.
By the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (1–3) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum sp. Their str...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/9/157 |
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| author | Lei Huang Wen-Jian Lan Rong Deng Gong-Kan Feng Qing-Yan Xu Zhi-Yu Hu Xiao-Feng Zhu Hou-Jin Li |
| author_facet | Lei Huang Wen-Jian Lan Rong Deng Gong-Kan Feng Qing-Yan Xu Zhi-Yu Hu Xiao-Feng Zhu Hou-Jin Li |
| author_sort | Lei Huang |
| collection | DOAJ |
| description | By the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (1–3) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 1–3 showed significant cytotoxicities against various cancer cell lines in vitro. |
| first_indexed | 2024-04-13T07:23:41Z |
| format | Article |
| id | doaj.art-8b4dc4c48a0c418dba791748a9fdc208 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T07:23:41Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8b4dc4c48a0c418dba791748a9fdc2082022-12-22T02:56:32ZengMDPI AGMarine Drugs1660-33972016-08-0114915710.3390/md14090157md14090157Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.Lei Huang0Wen-Jian Lan1Rong Deng2Gong-Kan Feng3Qing-Yan Xu4Zhi-Yu Hu5Xiao-Feng Zhu6Hou-Jin Li7School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, ChinaSchool of Life Sciences, Xiamen University, Xiamen 361102, ChinaSchool of Life Sciences, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, ChinaBy the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (1–3) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 1–3 showed significant cytotoxicities against various cancer cell lines in vitro.http://www.mdpi.com/1660-3397/14/9/157Chondrostereum sp.chondrosterinhirsutanesesquiterpenoidcytotoxicity |
| spellingShingle | Lei Huang Wen-Jian Lan Rong Deng Gong-Kan Feng Qing-Yan Xu Zhi-Yu Hu Xiao-Feng Zhu Hou-Jin Li Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp. Marine Drugs Chondrostereum sp. chondrosterin hirsutane sesquiterpenoid cytotoxicity |
| title | Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp. |
| title_full | Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp. |
| title_fullStr | Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp. |
| title_full_unstemmed | Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp. |
| title_short | Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp. |
| title_sort | additional new cytotoxic triquinane type sesquiterpenoids chondrosterins k m from the marine fungus chondrostereum sp |
| topic | Chondrostereum sp. chondrosterin hirsutane sesquiterpenoid cytotoxicity |
| url | http://www.mdpi.com/1660-3397/14/9/157 |
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