Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study
Abstract Purpose To determine the utility of short gamete coincubation in in vitro fertilization (IVF‐S) combined with early rescue intracytoplasmic sperm injection (R‐ICSI) and split IVF‐ICSI in preventing low fertilization based on a retrospective cohort study. Methods Couples with a high risk of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12420 |
| _version_ | 1797976018425741312 |
|---|---|
| author | Linlin Jiang Yifan Qian Xiaoli Chen Xiaohui Ji Songbang Ou Ruiqi Li Dongzi Yang Yu Li |
| author_facet | Linlin Jiang Yifan Qian Xiaoli Chen Xiaohui Ji Songbang Ou Ruiqi Li Dongzi Yang Yu Li |
| author_sort | Linlin Jiang |
| collection | DOAJ |
| description | Abstract Purpose To determine the utility of short gamete coincubation in in vitro fertilization (IVF‐S) combined with early rescue intracytoplasmic sperm injection (R‐ICSI) and split IVF‐ICSI in preventing low fertilization based on a retrospective cohort study. Methods Couples with a high risk of low IVF fertilization during the first ART cycle underwent IVF‐S with R‐ICSI or split IVF‐ICSI. Fertilization rate, embryo quality, and clinical outcomes were measured. Results After propensity score matching, we included 188 couples in the IVF‐S with R‐ICSI group as Group 1 and 720 in the split IVF‐ICSI group as Group 2. Normal fertilization rates were similar; however, Group 1 had a higher multiple pronuclei rate (10.42% vs. 4.50%, p < 0.001) but a higher embryo utilization rate (59.84% vs. 53.60%, p < 0.001). The groups were similar in the rates of high‐quality embryos, embryo implantation, clinical pregnancy, and live birth. Low IVF fertilization rate was 4.79% and 9.03% in Group 1 and Group 2, respectively, with similar fertilization rate and embryo development. Conclusion IVF‐S with early R‐ICSI and split IVF‐ICSI were effective strategies in preventing low fertilization rate. IVF‐S with early R‐ICSI could become the preferred approach because of its advantages—higher embryo utilization rate, fewer ICSI procedures, similar clinical pregnancy rate, and live birth rate. |
| first_indexed | 2024-04-11T04:44:38Z |
| format | Article |
| id | doaj.art-8b4e1e633bb24afcb9e68bfdb8dd0afc |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-04-11T04:44:38Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-8b4e1e633bb24afcb9e68bfdb8dd0afc2022-12-27T13:54:58ZengWileyReproductive Medicine and Biology1445-57811447-05782022-01-01211n/an/a10.1002/rmb2.12420Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort studyLinlin Jiang0Yifan Qian1Xiaoli Chen2Xiaohui Ji3Songbang Ou4Ruiqi Li5Dongzi Yang6Yu Li7Department of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology Sun Yat‐Sen Memorial HospitalSun Yat‐Sen University Guangzhou ChinaAbstract Purpose To determine the utility of short gamete coincubation in in vitro fertilization (IVF‐S) combined with early rescue intracytoplasmic sperm injection (R‐ICSI) and split IVF‐ICSI in preventing low fertilization based on a retrospective cohort study. Methods Couples with a high risk of low IVF fertilization during the first ART cycle underwent IVF‐S with R‐ICSI or split IVF‐ICSI. Fertilization rate, embryo quality, and clinical outcomes were measured. Results After propensity score matching, we included 188 couples in the IVF‐S with R‐ICSI group as Group 1 and 720 in the split IVF‐ICSI group as Group 2. Normal fertilization rates were similar; however, Group 1 had a higher multiple pronuclei rate (10.42% vs. 4.50%, p < 0.001) but a higher embryo utilization rate (59.84% vs. 53.60%, p < 0.001). The groups were similar in the rates of high‐quality embryos, embryo implantation, clinical pregnancy, and live birth. Low IVF fertilization rate was 4.79% and 9.03% in Group 1 and Group 2, respectively, with similar fertilization rate and embryo development. Conclusion IVF‐S with early R‐ICSI and split IVF‐ICSI were effective strategies in preventing low fertilization rate. IVF‐S with early R‐ICSI could become the preferred approach because of its advantages—higher embryo utilization rate, fewer ICSI procedures, similar clinical pregnancy rate, and live birth rate.https://doi.org/10.1002/rmb2.12420early rescue ICSIfirst ART cyclelow fertilizationshort gamete coincubationsplit IVF‐ICSI |
| spellingShingle | Linlin Jiang Yifan Qian Xiaoli Chen Xiaohui Ji Songbang Ou Ruiqi Li Dongzi Yang Yu Li Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study Reproductive Medicine and Biology early rescue ICSI first ART cycle low fertilization short gamete coincubation split IVF‐ICSI |
| title | Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study |
| title_full | Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study |
| title_fullStr | Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study |
| title_full_unstemmed | Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study |
| title_short | Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study |
| title_sort | effect of early rescue icsi and split ivf icsi in preventing low fertilization rate during the first art cycle a real world retrospective cohort study |
| topic | early rescue ICSI first ART cycle low fertilization short gamete coincubation split IVF‐ICSI |
| url | https://doi.org/10.1002/rmb2.12420 |
| work_keys_str_mv | AT linlinjiang effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT yifanqian effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT xiaolichen effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT xiaohuiji effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT songbangou effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT ruiqili effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT dongziyang effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy AT yuli effectofearlyrescueicsiandsplitivficsiinpreventinglowfertilizationrateduringthefirstartcyclearealworldretrospectivecohortstudy |