Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emergin...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Pharmaceutics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156723000105 |
| _version_ | 1797798676826947584 |
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| author | Lucía Rodríguez-Pombo Laura Martínez-Castro Xiaoyan Xu Jun Jie Ong Carlos Rial Daniel Nieto García Alejandro González-Santos Julian Flores-González Carmen Alvarez-Lorenzo Abdul W. Basit Alvaro Goyanes |
| author_facet | Lucía Rodríguez-Pombo Laura Martínez-Castro Xiaoyan Xu Jun Jie Ong Carlos Rial Daniel Nieto García Alejandro González-Santos Julian Flores-González Carmen Alvarez-Lorenzo Abdul W. Basit Alvaro Goyanes |
| author_sort | Lucía Rodríguez-Pombo |
| collection | DOAJ |
| description | 3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry. |
| first_indexed | 2024-03-13T04:07:27Z |
| format | Article |
| id | doaj.art-8b4e28c772b348f197681513b93ce79d |
| institution | Directory Open Access Journal |
| issn | 2590-1567 |
| language | English |
| last_indexed | 2024-03-13T04:07:27Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj.art-8b4e28c772b348f197681513b93ce79d2023-06-21T06:59:12ZengElsevierInternational Journal of Pharmaceutics: X2590-15672023-12-015100166Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printingLucía Rodríguez-Pombo0Laura Martínez-Castro1Xiaoyan Xu2Jun Jie Ong3Carlos Rial4Daniel Nieto García5Alejandro González-Santos6Julian Flores-González7Carmen Alvarez-Lorenzo8Abdul W. Basit9Alvaro Goyanes10Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKFabRx Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, UKComplex Tissue Regeneration Department, MERLIN Institute for Technology Inspired Regenerative Medicine, Universiteitssingel 40, 6229ER Maastricht, the NetherlandsFacultad de Física, Centro de Investigación en Tecnologías Inteligentes (CITIUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainFacultad de Física, Centro de Investigación en Tecnologías Inteligentes (CITIUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FabRx Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, UK; Corresponding authors at: Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain; Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FabRx Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, UK; Corresponding authors at: Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.http://www.sciencedirect.com/science/article/pii/S2590156723000105Vat photopolymerization 3D printed medicines3D rotary printingTomographic reconstruction3D printed drug productsPrinting pharmaceuticals and drug delivery systemsPersonalized formulations |
| spellingShingle | Lucía Rodríguez-Pombo Laura Martínez-Castro Xiaoyan Xu Jun Jie Ong Carlos Rial Daniel Nieto García Alejandro González-Santos Julian Flores-González Carmen Alvarez-Lorenzo Abdul W. Basit Alvaro Goyanes Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing International Journal of Pharmaceutics: X Vat photopolymerization 3D printed medicines 3D rotary printing Tomographic reconstruction 3D printed drug products Printing pharmaceuticals and drug delivery systems Personalized formulations |
| title | Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing |
| title_full | Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing |
| title_fullStr | Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing |
| title_full_unstemmed | Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing |
| title_short | Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing |
| title_sort | simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3d printing |
| topic | Vat photopolymerization 3D printed medicines 3D rotary printing Tomographic reconstruction 3D printed drug products Printing pharmaceuticals and drug delivery systems Personalized formulations |
| url | http://www.sciencedirect.com/science/article/pii/S2590156723000105 |
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