MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Summary: Maintenance of a healthy photoreceptor-retinal pigment epithelium (RPE) interface is essential for vision. At the center of this interface, apical membrane protrusions stemming from the RPE ensheath photoreceptor outer segments (POS), and are possibly involved in the recycling of POS throug...

Full description

Bibliographic Details
Main Authors:	Seba Almedawar, Katerina Vafia, Sven Schreiter, Katrin Neumann, Shahryar Khattak, Thomas Kurth, Marius Ader, Mike O. Karl, Stephen H. Tsang, Elly M. Tanaka
Format:	Article
Language:	English
Published:	Elsevier 2020-03-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671120300606

Similar Items

Outer segment formation of transplanted photoreceptor precursor cells.
by: Dominic Eberle, et al.
Published: (2012-01-01)

MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.
by: Shameka J Shelby, et al.
Published: (2013-01-01)

Stress reaction in outer segments of photoreceptors after blue light irradiation.
by: Cora Roehlecke, et al.
Published: (2013-01-01)

HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
by: Manuela Völkner, et al.
Published: (2022-10-01)

Comprehensive Analysis of Photoreceptor Outer Segments: Flow Cytometry Characterization and Stress-Driven Impact on Retinal Pigment Epithelium Phagocytosis
by: Haoqian Liang, et al.
Published: (2023-08-01)

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells
by: Karl J. Wahlin, et al.
Published: (2017-04-01)

Kif17 phosphorylation regulates photoreceptor outer segment turnover
by: Tylor R. Lewis, et al.
Published: (2018-11-01)

Regulation of bone homeostasis by MERTK and TYRO3
by: Janik Engelmann, et al.
Published: (2022-12-01)

Harnessing MerTK agonism for targeted therapeutics
by: Vivekananda Kedage, et al.
Published: (2020-01-01)

The Retinal Pigment Epithelium: a Convenient Source of New Photoreceptor cells?
by: Shu-Zhen Wang, et al.
Published: (2014-01-01)

Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.
by: Yu Zhu, et al.
Published: (2013-01-01)

Probing Photoreceptor Outer Segment Phagocytosis by the RPE In Vivo: Models and Methodologies
by: Jade A. Vargas, et al.
Published: (2022-03-01)

Transient Retention of Photoreceptor Outer Segments in Matrigel-Embedded Retinal Organoids
by: Patricia Berber, et al.
Published: (2022-11-01)

Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina
by: Sahar Pourhoseini, et al.
Published: (2021-02-01)

BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.
by: Ying Hsu, et al.
Published: (2017-10-01)

Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK
by: Yingyu Mao, et al.
Published: (2021-07-01)

Tyro3 Modulates Mertk-Associated Retinal Degeneration.
by: Douglas Vollrath, et al.
Published: (2015-12-01)

The role of endothelial MERTK during the inflammatory response in lungs.
by: Yitong Li, et al.
Published: (2019-01-01)

Macular outer nuclear layer, ellipsoid zone and outer photoreceptor segment band thickness, axial length and other determinants
by: Ya Xing Wang, et al.
Published: (2023-04-01)

TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments
by: Lital Remez, et al.
Published: (2020-11-01)

Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia.
by: Ingrid P Meschede, et al.
Published: (2020-01-01)

Olfactory ensheathing cells and neuropathic pain
by: Ji-peng Liu, et al.
Published: (2023-04-01)

Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factor
by: Yu Chen, et al.
Published: (2019-01-01)

Generation of induced pluripotent stem cell lines from three patients with Aicardi-Goutières syndrome type 5 due to biallelic SAMDH1 mutations
by: Vanessa Hänchen, et al.
Published: (2022-10-01)

Generation of induced pluripotent stem cell lines from two patients with Aicardi-Goutières syndrome type 1 due to biallelic TREX1 mutations
by: Vanessa Hänchen, et al.
Published: (2022-10-01)

Effective protection of photoreceptors using an inflammation-responsive hydrogel to attenuate outer retinal degeneration
by: Hyerim Kim, et al.
Published: (2023-12-01)

Photoreceptor outer segment layer thinning as a biomarker in acute central serous chorioretinopathy
by: Dmitrii S. Maltsev, et al.
Published: (2023-03-01)

Focal Functional and Microstructural Changes of Photoreceptors in Eyes with Acute Zonal Occult Outer Retinopathy
by: Keitetsu So, et al.
Published: (2011-09-01)

AAV vectors for FRET-based analysis of protein-protein interactions in photoreceptor outer segments
by: Elvir Becirovic, et al.
Published: (2016-07-01)

Deletion of prominin-1 in mice results in disrupted photoreceptor outer segment protein homeostasis
by: Yu-Shu Xiao, et al.
Published: (2021-09-01)

Generation of a genetically encoded marker of rod photoreceptor outer segment growth and renewal
by: John J. Willoughby, et al.
Published: (2011-10-01)

The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
by: Li Wang, et al.
Published: (2022-02-01)

Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
by: Linda T. Nguyen, et al.
Published: (2023-11-01)

Olfactory ensheathing cells in facial nerve regeneration
by: Manyi Li, et al.
Published: (2020-09-01)

Olfactory Ensheathing Cells for Spinal Cord Injury
by: R. Yao, et al.
Published: (2018-06-01)

Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death
by: Andy Shao, et al.
Published: (2022-07-01)

Structure and function of the retinal pigment epithelium, photoreceptors and cornea in the eye of Sardinella aurita (Clupeidae, Teleostei)
by: Mostafa Ali Salem
Published: (2016-05-01)

Localization of acetylcholine-related molecules in the retina: implication of the communication from photoreceptor to retinal pigment epithelium.
by: Hidetaka Matsumoto, et al.
Published: (2012-01-01)

Retinal sensitivity and photoreceptor arrangement changes secondary to congenital simple hamartoma of retinal pigment epithelium
by: M. W. Rodrigues, et al.
Published: (2019-01-01)

Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors.
by: West, E, et al.
Published: (2008)