Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not?
Abstract We have read the article “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, acti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-12-01
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| Series: | Clinical Hypertension |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40885-017-0082-0 |
| _version_ | 1819064420537466880 |
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| author | Venu Gopal Jonnalagadda Kanchan Choudhary Vijay Kranti Matety |
| author_facet | Venu Gopal Jonnalagadda Kanchan Choudhary Vijay Kranti Matety |
| author_sort | Venu Gopal Jonnalagadda |
| collection | DOAJ |
| description | Abstract We have read the article “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial” by GC Oh., et al. and found it quite interesting to learn the testing of effectiveness between amlodipine and hydrochlorothiazide in combination with losartan. After 4 weeks of therapy, non-responders were exposed for dose titration of losartan/amlodipine 100/5 mg daily or losartan/hydrochlorothiazide 100/25 mg daily. However, authors didn’t increase in the amlodipine dose from 5 to 10 mg from randomization. However, as per literature both drugs are non-significant in their blood pressure lowering effect. The clarification on above point will further allay the efficacy concerns of clinicians and result in wider usage of future published data. |
| first_indexed | 2024-12-21T15:30:17Z |
| format | Article |
| id | doaj.art-8b4ee689c16a4e89802e02b5662ad572 |
| institution | Directory Open Access Journal |
| issn | 2056-5909 |
| language | English |
| last_indexed | 2024-12-21T15:30:17Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Hypertension |
| spelling | doaj.art-8b4ee689c16a4e89802e02b5662ad5722022-12-21T18:58:47ZengBMCClinical Hypertension2056-59092017-12-012311210.1186/s40885-017-0082-0Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not?Venu Gopal Jonnalagadda0Kanchan Choudhary1Vijay Kranti Matety2Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and ResearchDepartment of Pharmacology & Toxicology, Bhupal Nobles’ Institute Of Pharmaceutical SciencesDepartment of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and ResearchAbstract We have read the article “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial” by GC Oh., et al. and found it quite interesting to learn the testing of effectiveness between amlodipine and hydrochlorothiazide in combination with losartan. After 4 weeks of therapy, non-responders were exposed for dose titration of losartan/amlodipine 100/5 mg daily or losartan/hydrochlorothiazide 100/25 mg daily. However, authors didn’t increase in the amlodipine dose from 5 to 10 mg from randomization. However, as per literature both drugs are non-significant in their blood pressure lowering effect. The clarification on above point will further allay the efficacy concerns of clinicians and result in wider usage of future published data.http://link.springer.com/article/10.1186/s40885-017-0082-0HypertensionCalcium channel blockersThiazide diureticsARB blockers |
| spellingShingle | Venu Gopal Jonnalagadda Kanchan Choudhary Vijay Kranti Matety Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not? Clinical Hypertension Hypertension Calcium channel blockers Thiazide diuretics ARB blockers |
| title | Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not? |
| title_full | Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not? |
| title_fullStr | Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not? |
| title_full_unstemmed | Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not? |
| title_short | Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not? |
| title_sort | amlodipine vs hydrochlorothiazide is there any disparity in its antihypertensive effect or not |
| topic | Hypertension Calcium channel blockers Thiazide diuretics ARB blockers |
| url | http://link.springer.com/article/10.1186/s40885-017-0082-0 |
| work_keys_str_mv | AT venugopaljonnalagadda amlodipinevshydrochlorothiazideisthereanydisparityinitsantihypertensiveeffectornot AT kanchanchoudhary amlodipinevshydrochlorothiazideisthereanydisparityinitsantihypertensiveeffectornot AT vijaykrantimatety amlodipinevshydrochlorothiazideisthereanydisparityinitsantihypertensiveeffectornot |