An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma
Yichen Peng,1,2,* Xia Wu,1,2,* Yurong Zhang,1 Yue Yin,1 Xianglin Chen,2 Ding Zheng,1 Jing Wang1 1The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Hepatobiliary Department, Luzhou, People’s Republic of China; 2Department of Integrated Traditional C...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/an-overview-of-traditional-chinese-medicine-in-the-treatment-after-rad-peer-reviewed-fulltext-article-JHC |
| _version_ | 1797385643176755200 |
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| author | Peng Y Wu X Zhang Y Yin Y Chen X Zheng D Wang J |
| author_facet | Peng Y Wu X Zhang Y Yin Y Chen X Zheng D Wang J |
| author_sort | Peng Y |
| collection | DOAJ |
| description | Yichen Peng,1,2,* Xia Wu,1,2,* Yurong Zhang,1 Yue Yin,1 Xianglin Chen,2 Ding Zheng,1 Jing Wang1 1The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Hepatobiliary Department, Luzhou, People’s Republic of China; 2Department of Integrated Traditional Chinese & Western Medicine, The Southwest Medical University, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ding Zheng; Jing Wang, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Hepatobiliary Department, No. 182, Chunhui Road, Luzhou, 646000, People’s Republic of China, Tel +86 19937071324, Email 793436166@qq.com; lywj68@126.comAbstract: According to the Barcelona Clinic Liver Cancer (BCLC) system, radical resection of early stage primary hepatocellular carcinoma (HCC) mainly includes liver transplantation, surgical resection, and radiofrequency ablation (RFA), which yield 5-year survival rates of about 70– 79%, 41.3– 69.5%, and 40– 70%, respectively. The tumor-free 5-year rate for HCC patients undergoing radical resection only reach up to 13.7 months, so the prevention of recurrence after radical resection of HCC is very important for the prognosis of patients. The traditional Chinese medicine (TCM) takes the approach of multitarget and overall-regulation to treat tumors, it can also independently present the “component-target-pathway” related to a particular disease, and its systematic and holistic characteristics can provide a personalized therapy based on symptoms of the patient by treating the patient as a whole. TCM as postoperative adjuvant therapy after radical resection of HCC in Barcelona Clinic liver cancer A or B stages, and the numerous clinical trials confirmed that the efficacy of TCM in the field of HCC has a significant effect, not only improving the prognosis and quality of life but also enhancing patient survival rate. However, with the characteristics of multi-target, multi-component, and multi-pathway, the specific mechanism of Chinese medicine in the treatment of diseases is still unclear. Because of the positive pharmacological activities of TCM in combating anti-tumors, the mechanism studies of TCM have demonstrated beneficial effects on the regulation of immune function, chronic inflammation, the proliferation and metastasis of liver cancer cells, autophagy, and cell signaling pathways related to liver cancer. Therefore, this article reviews the mechanism of traditional Chinese medicine in reducing the recurrence rate of HCC after radical resection.Keywords: traditional Chinese medicine, radical resection, hepatocellular carcinoma, recurrence |
| first_indexed | 2024-03-08T21:57:13Z |
| format | Article |
| id | doaj.art-8b51bfef583f4bb3bd2cda19096707ef |
| institution | Directory Open Access Journal |
| issn | 2253-5969 |
| language | English |
| last_indexed | 2024-03-08T21:57:13Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj.art-8b51bfef583f4bb3bd2cda19096707ef2023-12-19T17:37:32ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692023-12-01Volume 102305232189085An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular CarcinomaPeng YWu XZhang YYin YChen XZheng DWang JYichen Peng,1,2,* Xia Wu,1,2,* Yurong Zhang,1 Yue Yin,1 Xianglin Chen,2 Ding Zheng,1 Jing Wang1 1The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Hepatobiliary Department, Luzhou, People’s Republic of China; 2Department of Integrated Traditional Chinese & Western Medicine, The Southwest Medical University, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ding Zheng; Jing Wang, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Hepatobiliary Department, No. 182, Chunhui Road, Luzhou, 646000, People’s Republic of China, Tel +86 19937071324, Email 793436166@qq.com; lywj68@126.comAbstract: According to the Barcelona Clinic Liver Cancer (BCLC) system, radical resection of early stage primary hepatocellular carcinoma (HCC) mainly includes liver transplantation, surgical resection, and radiofrequency ablation (RFA), which yield 5-year survival rates of about 70– 79%, 41.3– 69.5%, and 40– 70%, respectively. The tumor-free 5-year rate for HCC patients undergoing radical resection only reach up to 13.7 months, so the prevention of recurrence after radical resection of HCC is very important for the prognosis of patients. The traditional Chinese medicine (TCM) takes the approach of multitarget and overall-regulation to treat tumors, it can also independently present the “component-target-pathway” related to a particular disease, and its systematic and holistic characteristics can provide a personalized therapy based on symptoms of the patient by treating the patient as a whole. TCM as postoperative adjuvant therapy after radical resection of HCC in Barcelona Clinic liver cancer A or B stages, and the numerous clinical trials confirmed that the efficacy of TCM in the field of HCC has a significant effect, not only improving the prognosis and quality of life but also enhancing patient survival rate. However, with the characteristics of multi-target, multi-component, and multi-pathway, the specific mechanism of Chinese medicine in the treatment of diseases is still unclear. Because of the positive pharmacological activities of TCM in combating anti-tumors, the mechanism studies of TCM have demonstrated beneficial effects on the regulation of immune function, chronic inflammation, the proliferation and metastasis of liver cancer cells, autophagy, and cell signaling pathways related to liver cancer. Therefore, this article reviews the mechanism of traditional Chinese medicine in reducing the recurrence rate of HCC after radical resection.Keywords: traditional Chinese medicine, radical resection, hepatocellular carcinoma, recurrencehttps://www.dovepress.com/an-overview-of-traditional-chinese-medicine-in-the-treatment-after-rad-peer-reviewed-fulltext-article-JHCtraditional chinese medicineradical resectionhepatocellular carcinomarecurrence |
| spellingShingle | Peng Y Wu X Zhang Y Yin Y Chen X Zheng D Wang J An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma Journal of Hepatocellular Carcinoma traditional chinese medicine radical resection hepatocellular carcinoma recurrence |
| title | An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma |
| title_full | An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma |
| title_fullStr | An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma |
| title_full_unstemmed | An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma |
| title_short | An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma |
| title_sort | overview of traditional chinese medicine in the treatment after radical resection of hepatocellular carcinoma |
| topic | traditional chinese medicine radical resection hepatocellular carcinoma recurrence |
| url | https://www.dovepress.com/an-overview-of-traditional-chinese-medicine-in-the-treatment-after-rad-peer-reviewed-fulltext-article-JHC |
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