Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants
Objectives: To compare the clinical characteristics and chest CT findings of patients infected with Omicron and Delta variants and the original strain of COVID-19. Methods: A total of 503 patients infected with the original strain (245 cases), Delta variant (90 cases), and Omicron variant (168 cases...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/901 |
| _version_ | 1827751112565850112 |
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| author | Xiaoyu Han Jingze Chen Lu Chen Xi Jia Yanqing Fan Yuting Zheng Osamah Alwalid Jie Liu Yumin Li Na Li Jin Gu Jiangtao Wang Heshui Shi |
| author_facet | Xiaoyu Han Jingze Chen Lu Chen Xi Jia Yanqing Fan Yuting Zheng Osamah Alwalid Jie Liu Yumin Li Na Li Jin Gu Jiangtao Wang Heshui Shi |
| author_sort | Xiaoyu Han |
| collection | DOAJ |
| description | Objectives: To compare the clinical characteristics and chest CT findings of patients infected with Omicron and Delta variants and the original strain of COVID-19. Methods: A total of 503 patients infected with the original strain (245 cases), Delta variant (90 cases), and Omicron variant (168 cases) were retrospectively analyzed. The differences in clinical severity and chest CT findings were analyzed. We also compared the infection severity of patients with different vaccination statuses and quantified pneumonia by a deep-learning approach. Results: The rate of severe disease decreased significantly from the original strain to the Delta variant and Omicron variant (27% vs. 10% vs. 4.8%, <i>p</i> < 0.001). In the Omicron group, 44% (73/168) of CT scans were categorized as abnormal compared with 81% (73/90) in the Delta group and 96% (235/245, <i>p</i> < 0.05) in the original group. Trends of a gradual decrease in total CT score, lesion volume, and lesion CT value of AI evaluation were observed across the groups (<i>p</i> < 0.001 for all). Omicron patients who received the booster vaccine had less clinical severity (<i>p</i> = 0.015) and lower lung involvement rate than those without the booster vaccine (36% vs. 57%, <i>p</i> = 0.009). Conclusions: Compared with the original strain and Delta variant, the Omicron variant had less clinical severity and less lung injury on CT scans. |
| first_indexed | 2024-03-11T06:53:41Z |
| format | Article |
| id | doaj.art-8b52b05f984748908b83faab3c7f4532 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:41Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8b52b05f984748908b83faab3c7f45322023-11-17T09:47:16ZengMDPI AGBiomedicines2227-90592023-03-0111390110.3390/biomedicines11030901Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron VariantsXiaoyu Han0Jingze Chen1Lu Chen2Xi Jia3Yanqing Fan4Yuting Zheng5Osamah Alwalid6Jie Liu7Yumin Li8Na Li9Jin Gu10Jiangtao Wang11Heshui Shi12Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Pharmacy, Wuhan Jinyintan Hospital, Wuhan 430022, ChinaDepartment of Radiology, Wuhan Jinyintan hospital, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Wuhan Jinyintan hospital, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Diagnostic Imaging, Sidra Medicine, Doha 26999, QatarDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaXiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaObjectives: To compare the clinical characteristics and chest CT findings of patients infected with Omicron and Delta variants and the original strain of COVID-19. Methods: A total of 503 patients infected with the original strain (245 cases), Delta variant (90 cases), and Omicron variant (168 cases) were retrospectively analyzed. The differences in clinical severity and chest CT findings were analyzed. We also compared the infection severity of patients with different vaccination statuses and quantified pneumonia by a deep-learning approach. Results: The rate of severe disease decreased significantly from the original strain to the Delta variant and Omicron variant (27% vs. 10% vs. 4.8%, <i>p</i> < 0.001). In the Omicron group, 44% (73/168) of CT scans were categorized as abnormal compared with 81% (73/90) in the Delta group and 96% (235/245, <i>p</i> < 0.05) in the original group. Trends of a gradual decrease in total CT score, lesion volume, and lesion CT value of AI evaluation were observed across the groups (<i>p</i> < 0.001 for all). Omicron patients who received the booster vaccine had less clinical severity (<i>p</i> = 0.015) and lower lung involvement rate than those without the booster vaccine (36% vs. 57%, <i>p</i> = 0.009). Conclusions: Compared with the original strain and Delta variant, the Omicron variant had less clinical severity and less lung injury on CT scans.https://www.mdpi.com/2227-9059/11/3/901SARS-CoV-2Delta variantOmicron variantoriginal strainCT imaging |
| spellingShingle | Xiaoyu Han Jingze Chen Lu Chen Xi Jia Yanqing Fan Yuting Zheng Osamah Alwalid Jie Liu Yumin Li Na Li Jin Gu Jiangtao Wang Heshui Shi Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants Biomedicines SARS-CoV-2 Delta variant Omicron variant original strain CT imaging |
| title | Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants |
| title_full | Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants |
| title_fullStr | Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants |
| title_full_unstemmed | Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants |
| title_short | Comparative Analysis of Clinical and CT Findings in Patients with SARS-CoV-2 Original Strain, Delta and Omicron Variants |
| title_sort | comparative analysis of clinical and ct findings in patients with sars cov 2 original strain delta and omicron variants |
| topic | SARS-CoV-2 Delta variant Omicron variant original strain CT imaging |
| url | https://www.mdpi.com/2227-9059/11/3/901 |
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