Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants
Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling, dysfunction, and failure. Cardiac myocytes pos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/5/760 |
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| author | Sun-Hee Woo Joon-Chul Kim Nipa Eslenur Tran Nguyet Trinh Long Nguyen Hoàng Do |
| author_facet | Sun-Hee Woo Joon-Chul Kim Nipa Eslenur Tran Nguyet Trinh Long Nguyen Hoàng Do |
| author_sort | Sun-Hee Woo |
| collection | DOAJ |
| description | Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling, dysfunction, and failure. Cardiac myocytes possess several ROS-producing pathways, such as mitochondrial electron transport chain, NADPH oxidases, and nitric oxide synthases, and have endogenous antioxidation mechanisms. Cardiac Ca<sup>2+</sup>-signaling toolkit proteins, as well as mitochondrial functions, are largely modulated by ROS under physiological and pathological conditions, thereby producing alterations in contraction, membrane conductivity, cell metabolism and cell growth and death. Mechanical stresses under hypertension, post-myocardial infarction, heart failure, and valve diseases are the main causes for stress-induced cardiac remodeling and functional failure, which are associated with ROS-induced pathogenesis. Experimental evidence demonstrates that many cardioprotective natural antioxidants, enriched in foods or herbs, exert beneficial effects on cardiac functions (Ca<sup>2+</sup> signal, contractility and rhythm), myocytes remodeling, inflammation and death in pathological hearts. The review may provide knowledge and insight into the modulation of cardiac pathogenesis by ROS and natural antioxidants. |
| first_indexed | 2024-03-10T11:31:49Z |
| format | Article |
| id | doaj.art-8b53aeb100634c21a8a733c96c7a80e1 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T11:31:49Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8b53aeb100634c21a8a733c96c7a80e12023-11-21T19:10:39ZengMDPI AGAntioxidants2076-39212021-05-0110576010.3390/antiox10050760Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural AntioxidantsSun-Hee Woo0Joon-Chul Kim1Nipa Eslenur2Tran Nguyet Trinh3Long Nguyen Hoàng Do4College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, KoreaNEXEL Co., 8F 55 Magokdong-ro, Gangseo-gu, Seoul 07802, KoreaCollege of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, KoreaCollege of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, KoreaCollege of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, KoreaHomeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling, dysfunction, and failure. Cardiac myocytes possess several ROS-producing pathways, such as mitochondrial electron transport chain, NADPH oxidases, and nitric oxide synthases, and have endogenous antioxidation mechanisms. Cardiac Ca<sup>2+</sup>-signaling toolkit proteins, as well as mitochondrial functions, are largely modulated by ROS under physiological and pathological conditions, thereby producing alterations in contraction, membrane conductivity, cell metabolism and cell growth and death. Mechanical stresses under hypertension, post-myocardial infarction, heart failure, and valve diseases are the main causes for stress-induced cardiac remodeling and functional failure, which are associated with ROS-induced pathogenesis. Experimental evidence demonstrates that many cardioprotective natural antioxidants, enriched in foods or herbs, exert beneficial effects on cardiac functions (Ca<sup>2+</sup> signal, contractility and rhythm), myocytes remodeling, inflammation and death in pathological hearts. The review may provide knowledge and insight into the modulation of cardiac pathogenesis by ROS and natural antioxidants.https://www.mdpi.com/2076-3921/10/5/760cardiac Ca<sup>2+</sup> signalingROSnatural antioxidantsmitochondriacardiac pathogenesis cardioprotective |
| spellingShingle | Sun-Hee Woo Joon-Chul Kim Nipa Eslenur Tran Nguyet Trinh Long Nguyen Hoàng Do Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants Antioxidants cardiac Ca<sup>2+</sup> signaling ROS natural antioxidants mitochondria cardiac pathogenesis cardioprotective |
| title | Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants |
| title_full | Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants |
| title_fullStr | Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants |
| title_full_unstemmed | Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants |
| title_short | Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants |
| title_sort | modulations of cardiac functions and pathogenesis by reactive oxygen species and natural antioxidants |
| topic | cardiac Ca<sup>2+</sup> signaling ROS natural antioxidants mitochondria cardiac pathogenesis cardioprotective |
| url | https://www.mdpi.com/2076-3921/10/5/760 |
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