Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer
Autophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation of their intrinsic molecular relationships is important for cancer prevention and treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible for this is not fully under...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13314 |
| _version_ | 1828146157863305216 |
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| author | Jida Chen Chuan Qin Yulu Zhou Yongxia Chen Misha Mao Jingjing Yang |
| author_facet | Jida Chen Chuan Qin Yulu Zhou Yongxia Chen Misha Mao Jingjing Yang |
| author_sort | Jida Chen |
| collection | DOAJ |
| description | Autophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation of their intrinsic molecular relationships is important for cancer prevention and treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible for this is not fully understood. Here, we demonstrate that metformin and lncRNA‐H19 can regulate both autophagy and ferroptosis. Autophagy inducers and H19 can reverse the production of lipid reactive oxygen species and the inhibition of autophagy induced by metformin. The present study suggests that metformin may induce ferroptosis by inhibiting autophagy via H19, and this discovery may facilitate the development of novel therapies for the treatment of breast cancer. |
| first_indexed | 2024-04-11T20:42:40Z |
| format | Article |
| id | doaj.art-8b543ad35e084e1596b62db5c2b504eb |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-04-11T20:42:40Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-8b543ad35e084e1596b62db5c2b504eb2022-12-22T04:04:08ZengWileyFEBS Open Bio2211-54632022-01-0112114615310.1002/2211-5463.13314Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancerJida Chen0Chuan Qin1Yulu Zhou2Yongxia Chen3Misha Mao4Jingjing Yang5Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou ChinaBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou ChinaBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou ChinaBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou ChinaBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou ChinaBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou ChinaAutophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation of their intrinsic molecular relationships is important for cancer prevention and treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible for this is not fully understood. Here, we demonstrate that metformin and lncRNA‐H19 can regulate both autophagy and ferroptosis. Autophagy inducers and H19 can reverse the production of lipid reactive oxygen species and the inhibition of autophagy induced by metformin. The present study suggests that metformin may induce ferroptosis by inhibiting autophagy via H19, and this discovery may facilitate the development of novel therapies for the treatment of breast cancer.https://doi.org/10.1002/2211-5463.13314autophagybreast cancerferroptosisH19metformin |
| spellingShingle | Jida Chen Chuan Qin Yulu Zhou Yongxia Chen Misha Mao Jingjing Yang Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer FEBS Open Bio autophagy breast cancer ferroptosis H19 metformin |
| title | Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer |
| title_full | Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer |
| title_fullStr | Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer |
| title_full_unstemmed | Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer |
| title_short | Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer |
| title_sort | metformin may induce ferroptosis by inhibiting autophagy via lncrna h19 in breast cancer |
| topic | autophagy breast cancer ferroptosis H19 metformin |
| url | https://doi.org/10.1002/2211-5463.13314 |
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