Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women.
<h4>Aim</h4>To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause.<h4>Methods</h4>Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collect...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0235174 |
| _version_ | 1818843541171863552 |
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| author | Julie Abildgaard Jeanette Tingstedt Yanan Zhao Hans Jakob Hartling Anette Tønnes Pedersen Birgitte Lindegaard Susanne Dam Nielsen |
| author_facet | Julie Abildgaard Jeanette Tingstedt Yanan Zhao Hans Jakob Hartling Anette Tønnes Pedersen Birgitte Lindegaard Susanne Dam Nielsen |
| author_sort | Julie Abildgaard |
| collection | DOAJ |
| description | <h4>Aim</h4>To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause.<h4>Methods</h4>Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause.<h4>Results</h4>Postmenopausal women tended to have higher leukocyte counts (5.4 x109 vs. 4.9 x109 cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x109 vs. 1.6 x109 cells/l, p = 0.01) and monocytes (0.5 x109 vs. 0.4 x109 cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-α (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-α, IL-1β and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/μl, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets.<h4>Conclusions</h4>Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings. |
| first_indexed | 2024-12-19T04:59:30Z |
| format | Article |
| id | doaj.art-8b54a51f1a084f6cbdb81b3ba6e5dac5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T04:59:30Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8b54a51f1a084f6cbdb81b3ba6e5dac52022-12-21T20:35:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01156e023517410.1371/journal.pone.0235174Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women.Julie AbildgaardJeanette TingstedtYanan ZhaoHans Jakob HartlingAnette Tønnes PedersenBirgitte LindegaardSusanne Dam Nielsen<h4>Aim</h4>To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause.<h4>Methods</h4>Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause.<h4>Results</h4>Postmenopausal women tended to have higher leukocyte counts (5.4 x109 vs. 4.9 x109 cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x109 vs. 1.6 x109 cells/l, p = 0.01) and monocytes (0.5 x109 vs. 0.4 x109 cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-α (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-α, IL-1β and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/μl, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets.<h4>Conclusions</h4>Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings.https://doi.org/10.1371/journal.pone.0235174 |
| spellingShingle | Julie Abildgaard Jeanette Tingstedt Yanan Zhao Hans Jakob Hartling Anette Tønnes Pedersen Birgitte Lindegaard Susanne Dam Nielsen Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women. PLoS ONE |
| title | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women. |
| title_full | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women. |
| title_fullStr | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women. |
| title_full_unstemmed | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women. |
| title_short | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women. |
| title_sort | increased systemic inflammation and altered distribution of t cell subsets in postmenopausal women |
| url | https://doi.org/10.1371/journal.pone.0235174 |
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