Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study
The efficacy of extended meropenem infusions in patients with nosocomial pneumonia is not well defined. Therefore, we compared the clinical outcomes of extended versus intermittent meropenem infusions in the treatment of nosocomial pneumonia. We performed a retrospective analysis of extended versus...
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MDPI AG
2023-10-01
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| Online Access: | https://www.mdpi.com/2079-6382/12/10/1542 |
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| author | Dong-gon Hyun Jarim Seo Su Yeon Lee Jee Hwan Ahn Sang-Bum Hong Chae-Man Lim Younsuck Koh Jin Won Huh |
| author_facet | Dong-gon Hyun Jarim Seo Su Yeon Lee Jee Hwan Ahn Sang-Bum Hong Chae-Man Lim Younsuck Koh Jin Won Huh |
| author_sort | Dong-gon Hyun |
| collection | DOAJ |
| description | The efficacy of extended meropenem infusions in patients with nosocomial pneumonia is not well defined. Therefore, we compared the clinical outcomes of extended versus intermittent meropenem infusions in the treatment of nosocomial pneumonia. We performed a retrospective analysis of extended versus intermittent meropenem infusions in adult patients who had been treated for nosocomial pneumonia at a medical ICU between 1 May 2018 and 30 April 2020. The primary outcome was mortality at 14 days. Overall, 64 patients who underwent an extended infusion and 97 with an intermittent infusion were included in this study. At 14 days, 10 (15.6%) patients in the extended group and 22 (22.7%) in the intermittent group had died (adjusted hazard ratio (HR), 0.55; 95% confidence interval (CI): 0.23–1.31; <i>p</i> = 0.174). In the subgroup analysis, significant differences in mortality at day 14 were observed in patients following empirical treatment with meropenem (adjusted HR, 0.17; 95% CI: 0.03–0.96; <i>p</i> = 0.045) and in Gram-negative pathogens identified by blood or sputum cultures (adjusted HR, 0.01; 95% CI: 0.01–0.83; <i>p</i> = 0.033). Extended infusion of meropenem compared with intermittent infusion as a treatment option for nosocomial pneumonia may have a potential advantage in specific populations. |
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| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T21:29:30Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8b5577bdfe9d45bca6959f2caec43b142023-11-19T15:26:57ZengMDPI AGAntibiotics2079-63822023-10-011210154210.3390/antibiotics12101542Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center StudyDong-gon Hyun0Jarim Seo1Su Yeon Lee2Jee Hwan Ahn3Sang-Bum Hong4Chae-Man Lim5Younsuck Koh6Jin Won Huh7Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Pharmacy, Asan Medical Centre, Seoul 05505, Republic of KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaThe efficacy of extended meropenem infusions in patients with nosocomial pneumonia is not well defined. Therefore, we compared the clinical outcomes of extended versus intermittent meropenem infusions in the treatment of nosocomial pneumonia. We performed a retrospective analysis of extended versus intermittent meropenem infusions in adult patients who had been treated for nosocomial pneumonia at a medical ICU between 1 May 2018 and 30 April 2020. The primary outcome was mortality at 14 days. Overall, 64 patients who underwent an extended infusion and 97 with an intermittent infusion were included in this study. At 14 days, 10 (15.6%) patients in the extended group and 22 (22.7%) in the intermittent group had died (adjusted hazard ratio (HR), 0.55; 95% confidence interval (CI): 0.23–1.31; <i>p</i> = 0.174). In the subgroup analysis, significant differences in mortality at day 14 were observed in patients following empirical treatment with meropenem (adjusted HR, 0.17; 95% CI: 0.03–0.96; <i>p</i> = 0.045) and in Gram-negative pathogens identified by blood or sputum cultures (adjusted HR, 0.01; 95% CI: 0.01–0.83; <i>p</i> = 0.033). Extended infusion of meropenem compared with intermittent infusion as a treatment option for nosocomial pneumonia may have a potential advantage in specific populations.https://www.mdpi.com/2079-6382/12/10/1542meropenemintensive care unitpneumoniaventilator-associated pneumoniaintravenous infusion |
| spellingShingle | Dong-gon Hyun Jarim Seo Su Yeon Lee Jee Hwan Ahn Sang-Bum Hong Chae-Man Lim Younsuck Koh Jin Won Huh Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study Antibiotics meropenem intensive care unit pneumonia ventilator-associated pneumonia intravenous infusion |
| title | Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study |
| title_full | Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study |
| title_fullStr | Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study |
| title_full_unstemmed | Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study |
| title_short | Extended Versus Intermittent Meropenem Infusion in the Treatment of Nosocomial Pneumonia: A Retrospective Single-Center Study |
| title_sort | extended versus intermittent meropenem infusion in the treatment of nosocomial pneumonia a retrospective single center study |
| topic | meropenem intensive care unit pneumonia ventilator-associated pneumonia intravenous infusion |
| url | https://www.mdpi.com/2079-6382/12/10/1542 |
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