Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter
Background: Medullary Thyroid Carcinoma (MTC) is a malignancy that primarily arises from the C-cells of the thyroid gland with a tendency to regional and distant metastases. Methods: We report a case of a 34-year-old female with MTC where there was no evidence of primary foci of the disease within t...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Otolaryngology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S246854881730036X |
| _version_ | 1811308385916682240 |
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| author | Samiah S. Al-Angari Mohammed AlEssa Tariq Al-Johani |
| author_facet | Samiah S. Al-Angari Mohammed AlEssa Tariq Al-Johani |
| author_sort | Samiah S. Al-Angari |
| collection | DOAJ |
| description | Background: Medullary Thyroid Carcinoma (MTC) is a malignancy that primarily arises from the C-cells of the thyroid gland with a tendency to regional and distant metastases.
Methods: We report a case of a 34-year-old female with MTC where there was no evidence of primary foci of the disease within the thyroid gland, while there was a widespread metastasis in the cervical lymph nodes, lungs, abdomen, and vertebrae.
Results: The patient was diagnosed with metastatic sporadic MTC based on the pre-operative work up. She underwent completion thyroidectomy with bilateral neck dissection levels II-VI. The post-operative histopathology report confirmed the diagnosis.
Conclusion: The case report shows an unusual presentation of MTC. It demonstrates that there is an entity of metastatic sporadic MTC, confirmed by an abnormal calcitonin level, with unknown primary. |
| first_indexed | 2024-04-13T09:22:14Z |
| format | Article |
| id | doaj.art-8b55f258017c4789850592b20e7d39c4 |
| institution | Directory Open Access Journal |
| issn | 2468-5488 |
| language | English |
| last_indexed | 2024-04-13T09:22:14Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Otolaryngology Case Reports |
| spelling | doaj.art-8b55f258017c4789850592b20e7d39c42022-12-22T02:52:33ZengElsevierOtolaryngology Case Reports2468-54882018-03-016C313310.1016/j.xocr.2017.12.003Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular GoiterSamiah S. Al-Angari0Mohammed AlEssa1Tariq Al-Johani2Department of Otolaryngology – Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi ArabiaDepartment of Otolaryngology – Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi ArabiaDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi ArabiaBackground: Medullary Thyroid Carcinoma (MTC) is a malignancy that primarily arises from the C-cells of the thyroid gland with a tendency to regional and distant metastases. Methods: We report a case of a 34-year-old female with MTC where there was no evidence of primary foci of the disease within the thyroid gland, while there was a widespread metastasis in the cervical lymph nodes, lungs, abdomen, and vertebrae. Results: The patient was diagnosed with metastatic sporadic MTC based on the pre-operative work up. She underwent completion thyroidectomy with bilateral neck dissection levels II-VI. The post-operative histopathology report confirmed the diagnosis. Conclusion: The case report shows an unusual presentation of MTC. It demonstrates that there is an entity of metastatic sporadic MTC, confirmed by an abnormal calcitonin level, with unknown primary.http://www.sciencedirect.com/science/article/pii/S246854881730036XMedullary thyroid carcinomaThyroidMetastasisUnknown primaryGoiter |
| spellingShingle | Samiah S. Al-Angari Mohammed AlEssa Tariq Al-Johani Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter Otolaryngology Case Reports Medullary thyroid carcinoma Thyroid Metastasis Unknown primary Goiter |
| title | Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter |
| title_full | Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter |
| title_fullStr | Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter |
| title_full_unstemmed | Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter |
| title_short | Unusual presentation of medullary thyroid carcinoma: Regional and distant metastases in the background of benign non-neoplastic Multi-Nodular Goiter |
| title_sort | unusual presentation of medullary thyroid carcinoma regional and distant metastases in the background of benign non neoplastic multi nodular goiter |
| topic | Medullary thyroid carcinoma Thyroid Metastasis Unknown primary Goiter |
| url | http://www.sciencedirect.com/science/article/pii/S246854881730036X |
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