Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection
Background & Aims: In addition to HBV/HCV causing hepatocellular carcinoma (HCC), other risk factors including obesity and alcohol drinking also increase risk. We describe the cumulative risk of HCC and mortality from liver-related disease by selected modifiable risk factors among a non-hepa...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | JHEP Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555921001865 |
| _version_ | 1828136817407295488 |
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| author | Hui-Chen Wu Wen-Juei Jeng Mei-Hung Pan Yi-Chung Hsieh Sheng-Nan Lu Chien-Jen Chen Hwai-I. Yang |
| author_facet | Hui-Chen Wu Wen-Juei Jeng Mei-Hung Pan Yi-Chung Hsieh Sheng-Nan Lu Chien-Jen Chen Hwai-I. Yang |
| author_sort | Hui-Chen Wu |
| collection | DOAJ |
| description | Background & Aims: In addition to HBV/HCV causing hepatocellular carcinoma (HCC), other risk factors including obesity and alcohol drinking also increase risk. We describe the cumulative risk of HCC and mortality from liver-related disease by selected modifiable risk factors among a non-hepatitis virus-infected population. Methods: For a community-based cohort, residents aged 30–65 years living in 7 townships in Taiwan were recruited, and have been followed up since 1991. A total of 18,541 individuals were seronegative for markers of chronic infection of HBV/HCV and with no history of HCC at baseline. New non-HBV/HCV HCC cases and liver-related deaths were ascertained through data linkage to the National Cancer Registry and Death Certification System from 1 January 1991 through 31 December 2017. Results: There were 207 HCC cases and 215 liver-related deaths identified. The incidence rate of non-HBV/HCV HCC was 47.2 per 100,000 person-years. The mortality rate of liver-related death was 49.0 per 100,000 person-years. Baseline information on alcohol consumption, heart disease, diabetes, elevated aspartate aminotransferase, and alanine aminotransferase predicted higher risks of HCC, with hazard ratios (HRs) (95% CIs) of 1.7 (1.1–2.5), 2.2 (1.1–4.1), 1.9 (1.0–3.5), 1.7 (1.1–2.4), and 1.6 (1.0–2.4), respectively. The HRs (95% CIs) of liver-related death were 2.3 (1.6–3.2) for alcohol consumption, 1.4 (1.1–1.9) for BMI ≥25 kg/m2, 2.2 (1.4–3.3) for elevated aspartate aminotransferase, and 1.5 (1.0–2.4) for elevated alanine aminotransferase. The HR (95% CI) was 8.1 (3.6–18.5) for those with diabetes and elevated aspartate aminotransferase. Conclusions: Individuals with elevated liver enzymes are at high risk of liver disease. Prevention and treatment of diabetes and heart disease are critical for non-hepatitis B, non-hepatitis C (NonB/C)-HCC. Lay summary: We followed up individuals with no chronic HBV or HCV infection and described the risk of hepatocellular carcinoma (HCC, the most common form of primary liver cancer) and mortality from liver-related disease by modifiable risk factors. This study estimated the incidence rate of HCC by selected lifestyle risk factors and chronic diseases conditions. Alcohol consumption, heart disease, diabetes, and abnormal blood liver function tests showed a strong association with HCC risk and mortality. |
| first_indexed | 2024-04-11T18:09:51Z |
| format | Article |
| id | doaj.art-8b57634359fc49fdb046effa88592ace |
| institution | Directory Open Access Journal |
| issn | 2589-5559 |
| language | English |
| last_indexed | 2024-04-11T18:09:51Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHEP Reports |
| spelling | doaj.art-8b57634359fc49fdb046effa88592ace2022-12-22T04:10:09ZengElsevierJHEP Reports2589-55592022-02-0142100410Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infectionHui-Chen Wu0Wen-Juei Jeng1Mei-Hung Pan2Yi-Chung Hsieh3Sheng-Nan Lu4Chien-Jen Chen5Hwai-I. Yang6Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 West 168th St, Room P&S 16–421E, New York, NY 10032, USA. Phone:+1-212-305-6960Division of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan; College of Medicine, Chang Gung University, Taoyuan City, TaiwanGenomics Research Center, Academia Sinica, Taipei, TaiwanDivision of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan; College of Medicine, Chang Gung University, Taoyuan City, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, ChiayiChang Gung Memorial Hospital, Chiayi, TaiwanGenomics Research Center, Academia Sinica, Taipei, Taiwan; Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanGenomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan; Corresponding authors. Addresses: Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Taipei 115, Taiwan. Fax: +886-2-2789-8784; Phone:+886-2-2787-1308Background & Aims: In addition to HBV/HCV causing hepatocellular carcinoma (HCC), other risk factors including obesity and alcohol drinking also increase risk. We describe the cumulative risk of HCC and mortality from liver-related disease by selected modifiable risk factors among a non-hepatitis virus-infected population. Methods: For a community-based cohort, residents aged 30–65 years living in 7 townships in Taiwan were recruited, and have been followed up since 1991. A total of 18,541 individuals were seronegative for markers of chronic infection of HBV/HCV and with no history of HCC at baseline. New non-HBV/HCV HCC cases and liver-related deaths were ascertained through data linkage to the National Cancer Registry and Death Certification System from 1 January 1991 through 31 December 2017. Results: There were 207 HCC cases and 215 liver-related deaths identified. The incidence rate of non-HBV/HCV HCC was 47.2 per 100,000 person-years. The mortality rate of liver-related death was 49.0 per 100,000 person-years. Baseline information on alcohol consumption, heart disease, diabetes, elevated aspartate aminotransferase, and alanine aminotransferase predicted higher risks of HCC, with hazard ratios (HRs) (95% CIs) of 1.7 (1.1–2.5), 2.2 (1.1–4.1), 1.9 (1.0–3.5), 1.7 (1.1–2.4), and 1.6 (1.0–2.4), respectively. The HRs (95% CIs) of liver-related death were 2.3 (1.6–3.2) for alcohol consumption, 1.4 (1.1–1.9) for BMI ≥25 kg/m2, 2.2 (1.4–3.3) for elevated aspartate aminotransferase, and 1.5 (1.0–2.4) for elevated alanine aminotransferase. The HR (95% CI) was 8.1 (3.6–18.5) for those with diabetes and elevated aspartate aminotransferase. Conclusions: Individuals with elevated liver enzymes are at high risk of liver disease. Prevention and treatment of diabetes and heart disease are critical for non-hepatitis B, non-hepatitis C (NonB/C)-HCC. Lay summary: We followed up individuals with no chronic HBV or HCV infection and described the risk of hepatocellular carcinoma (HCC, the most common form of primary liver cancer) and mortality from liver-related disease by modifiable risk factors. This study estimated the incidence rate of HCC by selected lifestyle risk factors and chronic diseases conditions. Alcohol consumption, heart disease, diabetes, and abnormal blood liver function tests showed a strong association with HCC risk and mortality.http://www.sciencedirect.com/science/article/pii/S2589555921001865Alcohol drinkingCumulative incidenceDiabetesEpidemiologyHepatocellular carcinomaLiver-related death |
| spellingShingle | Hui-Chen Wu Wen-Juei Jeng Mei-Hung Pan Yi-Chung Hsieh Sheng-Nan Lu Chien-Jen Chen Hwai-I. Yang Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection JHEP Reports Alcohol drinking Cumulative incidence Diabetes Epidemiology Hepatocellular carcinoma Liver-related death |
| title | Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection |
| title_full | Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection |
| title_fullStr | Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection |
| title_full_unstemmed | Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection |
| title_short | Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic HBV/HCV infection |
| title_sort | incidence of hepatocellular carcinoma in a community based taiwanese population without chronic hbv hcv infection |
| topic | Alcohol drinking Cumulative incidence Diabetes Epidemiology Hepatocellular carcinoma Liver-related death |
| url | http://www.sciencedirect.com/science/article/pii/S2589555921001865 |
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