A Phase I Study of High-Dose Calcitriol in Combination with Temozolomide for Patients with Metastatic Melanoma

A Phase I Study of High-Dose Calcitriol in Combination with Temozolomide for Patients with Metastatic Melanoma

Background: Temozolomide is efficacious as an oral alternative for patients with metastatic melanoma (MM). Calcitriol has anti-proliferative properties and vitamin D receptor (VDR) polymorphisms are associated with alterations in melanoma susceptibility and progression. Methods: Tem 150 mg/m2 was ad...

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Bibliographic Details
Main Authors: Erin Pettijohn, Brenda Martone, Alfred Rademaker, Timothy Kuzel
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Journal of Personalized Medicine
Subjects:
metastatic melanoma
vitamin D receptor polymorphisms
temozolomide
calcitriol
Taq1
Fok1
Online Access:http://www.mdpi.com/2075-4426/4/4/448

Internet

http://www.mdpi.com/2075-4426/4/4/448

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