Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy
Interleukin (IL)-33 is a key cytokine involved in type-2 immunity and allergic airway disease. At the level of lung epithelial cells, where it is clearly expressed, IL-33 plays an important role in both innate and adaptive immune responses in mucosal organs. It has been widely demonstrated that in t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/3/715 |
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| author | Giuseppe Murdaca Francesca Paladin Alessandro Tonacci Matteo Borro Monica Greco Alessandra Gerosa Stefania Isola Alessandro Allegra Sebastiano Gangemi |
| author_facet | Giuseppe Murdaca Francesca Paladin Alessandro Tonacci Matteo Borro Monica Greco Alessandra Gerosa Stefania Isola Alessandro Allegra Sebastiano Gangemi |
| author_sort | Giuseppe Murdaca |
| collection | DOAJ |
| description | Interleukin (IL)-33 is a key cytokine involved in type-2 immunity and allergic airway disease. At the level of lung epithelial cells, where it is clearly expressed, IL-33 plays an important role in both innate and adaptive immune responses in mucosal organs. It has been widely demonstrated that in the course of respiratory virus infections, the release of IL-33 increases, with consequent pro-inflammatory effects and consequent exacerbation of the clinical symptoms of chronic respiratory diseases. In our work, we analyzed the pathogenetic and prognostic involvement of IL-33 during the main respiratory viral infections, with particular interest in the recent SARS-CoV-2virus pandemic and the aim of determining a possible connection point on which to act with a targeted therapy that is able to improve the clinical outcome of patients. |
| first_indexed | 2024-03-09T13:49:15Z |
| format | Article |
| id | doaj.art-8b5c5b773b814dc99d0343cb550f46d6 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:49:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8b5c5b773b814dc99d0343cb550f46d62023-11-30T20:53:32ZengMDPI AGBiomedicines2227-90592022-03-0110371510.3390/biomedicines10030715Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized TherapyGiuseppe Murdaca0Francesca Paladin1Alessandro Tonacci2Matteo Borro3Monica Greco4Alessandra Gerosa5Stefania Isola6Alessandro Allegra7Sebastiano Gangemi8Department of Internal Medicine, Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Internal Medicine, Ospedale Policlinico San Martino, 16132 Genoa, ItalyClinical Physiology Institute, National Research Council of Italy (IFC-CNR), 56124 Pisa, ItalyInternal Medicine Department, San Paolo Hospital, 17100 Savona, ItalyInternal Medicine Department, San Paolo Hospital, 17100 Savona, ItalyDepartment of Internal Medicine, Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, Division of Hematology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyInterleukin (IL)-33 is a key cytokine involved in type-2 immunity and allergic airway disease. At the level of lung epithelial cells, where it is clearly expressed, IL-33 plays an important role in both innate and adaptive immune responses in mucosal organs. It has been widely demonstrated that in the course of respiratory virus infections, the release of IL-33 increases, with consequent pro-inflammatory effects and consequent exacerbation of the clinical symptoms of chronic respiratory diseases. In our work, we analyzed the pathogenetic and prognostic involvement of IL-33 during the main respiratory viral infections, with particular interest in the recent SARS-CoV-2virus pandemic and the aim of determining a possible connection point on which to act with a targeted therapy that is able to improve the clinical outcome of patients.https://www.mdpi.com/2227-9059/10/3/715IL-33chronic lung diseasesrespiratory viral infectionSARS-CoV-2biological drugs |
| spellingShingle | Giuseppe Murdaca Francesca Paladin Alessandro Tonacci Matteo Borro Monica Greco Alessandra Gerosa Stefania Isola Alessandro Allegra Sebastiano Gangemi Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy Biomedicines IL-33 chronic lung diseases respiratory viral infection SARS-CoV-2 biological drugs |
| title | Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy |
| title_full | Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy |
| title_fullStr | Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy |
| title_full_unstemmed | Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy |
| title_short | Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy |
| title_sort | involvement of il 33 in the pathogenesis and prognosis of major respiratory viral infections future perspectives for personalized therapy |
| topic | IL-33 chronic lung diseases respiratory viral infection SARS-CoV-2 biological drugs |
| url | https://www.mdpi.com/2227-9059/10/3/715 |
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