Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
Abstract The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait...
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| Format: | Article |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-98032-6 |
| _version_ | 1818683164806086656 |
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| author | Chun Il Park Hae Won Kim Syung Shick Hwang Jee In Kang Se Joo Kim |
| author_facet | Chun Il Park Hae Won Kim Syung Shick Hwang Jee In Kang Se Joo Kim |
| author_sort | Chun Il Park |
| collection | DOAJ |
| description | Abstract The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait resilience in male patients with AUD. In addition, allele-specific associations between FKBP5 DNA methylation and resilience were examined. In total, 297 men with AUD were assessed for alcohol use severity, childhood trauma, resilience, and impulsivity. Genotyping for FKBP5 rs1360780 and DNA methylation were analyzed. The effects of the rs1360780 single nucleotide polymorphism (SNP) and clinical variables on resilience were tested using linear regression analysis. Possible associations between FKBP5 DNA methylation and resilience were tested with partial correlation analysis. The rs1360780 risk allele, a low education level, and high impulsivity were associated with diminished resilience, whereas no significant main or interaction effect of childhood trauma with the SNP rs1360780 genotype on resilience was shown. No significant association between FKBP5 DNA methylation and resilience was found. The present study demonstrated the involvement of the rs1360780 risk allele in trait resilience in men with AUD, suggesting that the genetic vulnerability of FKBP5 may influence resilience related to AUD. |
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| id | doaj.art-8b5d553cd7344cb48e1d9d59c372b6d0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:30:23Z |
| publishDate | 2021-09-01 |
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| spelling | doaj.art-8b5d553cd7344cb48e1d9d59c372b6d02022-12-21T21:52:32ZengNature PortfolioScientific Reports2045-23222021-09-011111710.1038/s41598-021-98032-6Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorderChun Il Park0Hae Won Kim1Syung Shick Hwang2Jee In Kang3Se Joo Kim4Department of Psychiatry, CHA Bundang Medical Center, CHA UniversityInstitute of Behavioral Science in Medicine, Yonsei University College of MedicineYonsei Empathy Psychiatric ClinicInstitute of Behavioral Science in Medicine, Yonsei University College of MedicineInstitute of Behavioral Science in Medicine, Yonsei University College of MedicineAbstract The FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait resilience in male patients with AUD. In addition, allele-specific associations between FKBP5 DNA methylation and resilience were examined. In total, 297 men with AUD were assessed for alcohol use severity, childhood trauma, resilience, and impulsivity. Genotyping for FKBP5 rs1360780 and DNA methylation were analyzed. The effects of the rs1360780 single nucleotide polymorphism (SNP) and clinical variables on resilience were tested using linear regression analysis. Possible associations between FKBP5 DNA methylation and resilience were tested with partial correlation analysis. The rs1360780 risk allele, a low education level, and high impulsivity were associated with diminished resilience, whereas no significant main or interaction effect of childhood trauma with the SNP rs1360780 genotype on resilience was shown. No significant association between FKBP5 DNA methylation and resilience was found. The present study demonstrated the involvement of the rs1360780 risk allele in trait resilience in men with AUD, suggesting that the genetic vulnerability of FKBP5 may influence resilience related to AUD.https://doi.org/10.1038/s41598-021-98032-6 |
| spellingShingle | Chun Il Park Hae Won Kim Syung Shick Hwang Jee In Kang Se Joo Kim Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder Scientific Reports |
| title | Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder |
| title_full | Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder |
| title_fullStr | Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder |
| title_full_unstemmed | Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder |
| title_short | Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder |
| title_sort | genetic association of fkbp5 with trait resilience in korean male patients with alcohol use disorder |
| url | https://doi.org/10.1038/s41598-021-98032-6 |
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