Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway

Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway

Diabetic neuropathy is a chronic condition that affects a significant number of individuals with diabetes. Streptozotocin injection intraperitoneally to rodents produces pancreatic islet β-cell destruction causing hyperglycemia, which affect the brain leading to memory and cognition impairment. Dapa...

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Bibliographic Details
Main Authors: Hala El-Safty, Ashraf Ismail, Rania M. Abdelsalam, Ayman E. El-Sahar, Muhammed A. Saad
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Brain Research Bulletin
Subjects:
Diabetic neuropathy
Memory and cognition
Dapagliflozin
Wnt/β-catenin
CREB
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022000260

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