Deciphering tissue heterogeneity from spatially resolved transcriptomics by the autoencoder-assisted graph convolutional neural network
Spatially resolved transcriptomics (SRT) provides an unprecedented opportunity to investigate the complex and heterogeneous tissue organization. However, it is challenging for a single model to learn an effective representation within and across spatial contexts. To solve the issue, we develop a nov...
Main Authors: | Xinxing Li, Wendong Huang, Xuan Xu, Hong-Yu Zhang, Qianqian Shi |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-05-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1202409/full |
Similar Items
-
Promise of spatially resolved omics for tumor research
by: Yanhe Zhou, et al.
Published: (2023-08-01) -
Spatially resolved transcriptomics provide a new method for cancer research
by: Bowen Zheng, et al.
Published: (2022-05-01) -
Spatially-resolved proteomics and transcriptomics: An emerging digital spatial profiling approach for tumor microenvironment
by: Wang Nan, et al.
Published: (2021-01-01) -
SINFONIA: Scalable Identification of Spatially Variable Genes for Deciphering Spatial Domains
by: Rui Jiang, et al.
Published: (2023-02-01) -
Drug-target interaction prediction based on spatial consistency constraint and graph convolutional autoencoder
by: Peng Chen, et al.
Published: (2023-04-01)