Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran
Objectives:Chlamydia trachomatis infects the urogenital tract and eyes. Anatomical tropism is correlated with serovars which are characterized according to the variation in the major outer membrane proteins encoded by the ompA gene. The aim of the present study was to determine the distribution of C...
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| Format: | Article |
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Galenos Yayinevi
2023-08-01
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| Series: | Türk Oftalmoloji Dergisi |
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http://www.oftalmoloji.org/archives/archive-detail/article-preview/ichlamydia-trachomatis-i-serovar-distribution-in-p/61592
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| author | Zohreh Abedifar Fatemeh Fallah Fahimeh Asadiamoli Ben Bourrie Farahnoosh Doustdar |
| author_facet | Zohreh Abedifar Fatemeh Fallah Fahimeh Asadiamoli Ben Bourrie Farahnoosh Doustdar |
| author_sort | Zohreh Abedifar |
| collection | DOAJ |
| description | Objectives:Chlamydia trachomatis infects the urogenital tract and eyes. Anatomical tropism is correlated with serovars which are characterized according to the variation in the major outer membrane proteins encoded by the ompA gene. The aim of the present study was to determine the distribution of C. trachomatis serovars among patients with follicular conjunctivitis in Iran.Materials and Methods:A total of 68 conjunctival specimens from symptomatic adults were studied for the presence of C. trachomatis using polymerase chain reaction (PCR) analysis. Serovars were determined by Omp1 PCR-RFLP analysis.Results:C. trachomatis was detected in 38 (55.9%) of patients with follicular conjunctivitis, with higher C. trachomatis prevalence in the younger age groups. Twenty-six (38.2%) of these patients had a history of urinary tract infection. Four distinct serovars were identified in the conjunctiva samples using molecular genotyping. The most prevalent was serovar E, followed by G, I, and F.Conclusion:Our serovar distribution indicated that chlamydial follicular conjunctivitis usually has a genital source. Genital serovars may cause eye diseases, especially in sexually active adults. On the other hand, conjunctivitis might be the only sign of sexually transmitted infection. Therefore, genotyping C. trachomatis in ocular and genital specimens could be beneficial for acquiring more detailed epidemiological information about the etiology of the disease and monitoring treatment success. |
| first_indexed | 2024-03-12T14:00:55Z |
| format | Article |
| id | doaj.art-8b63d879fe5645b49e67916da0521d31 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-03-12T14:00:55Z |
| publishDate | 2023-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-8b63d879fe5645b49e67916da0521d312023-08-22T07:14:03ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612023-08-0153421822110.4274/tjo.galenos.2022.1208013049054Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in IranZohreh Abedifar0Fatemeh Fallah1Fahimeh Asadiamoli2Ben Bourrie3Farahnoosh Doustdar4 Shahid Beheshti Tıp Bilimleri Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, Tahran, İran Shahid Beheshti Tıp Bilimleri Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, Tahran, İran Tahran Tıp Bilimleri Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Tahran, İran Tehran University of Medical Sciences Faculty of Medicine, Department of Pathology, Tehran, Iran Shahid Beheshti Tıp Bilimleri Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, Tahran, İran Objectives:Chlamydia trachomatis infects the urogenital tract and eyes. Anatomical tropism is correlated with serovars which are characterized according to the variation in the major outer membrane proteins encoded by the ompA gene. The aim of the present study was to determine the distribution of C. trachomatis serovars among patients with follicular conjunctivitis in Iran.Materials and Methods:A total of 68 conjunctival specimens from symptomatic adults were studied for the presence of C. trachomatis using polymerase chain reaction (PCR) analysis. Serovars were determined by Omp1 PCR-RFLP analysis.Results:C. trachomatis was detected in 38 (55.9%) of patients with follicular conjunctivitis, with higher C. trachomatis prevalence in the younger age groups. Twenty-six (38.2%) of these patients had a history of urinary tract infection. Four distinct serovars were identified in the conjunctiva samples using molecular genotyping. The most prevalent was serovar E, followed by G, I, and F.Conclusion:Our serovar distribution indicated that chlamydial follicular conjunctivitis usually has a genital source. Genital serovars may cause eye diseases, especially in sexually active adults. On the other hand, conjunctivitis might be the only sign of sexually transmitted infection. Therefore, genotyping C. trachomatis in ocular and genital specimens could be beneficial for acquiring more detailed epidemiological information about the etiology of the disease and monitoring treatment success. http://www.oftalmoloji.org/archives/archive-detail/article-preview/ichlamydia-trachomatis-i-serovar-distribution-in-p/61592 chlamydia trachomatisfollicular conjunctivitisserotypepcrrflp |
| spellingShingle | Zohreh Abedifar Fatemeh Fallah Fahimeh Asadiamoli Ben Bourrie Farahnoosh Doustdar Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran Türk Oftalmoloji Dergisi chlamydia trachomatis follicular conjunctivitis serotype pcr rflp |
| title | Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran |
| title_full | Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran |
| title_fullStr | Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran |
| title_full_unstemmed | Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran |
| title_short | Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran |
| title_sort | chlamydia trachomatis serovar distribution in patients with follicular conjunctivitis in iran |
| topic | chlamydia trachomatis follicular conjunctivitis serotype pcr rflp |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/ichlamydia-trachomatis-i-serovar-distribution-in-p/61592
|
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