Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magneti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/75540 |
| _version_ | 1828167805025910784 |
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| author | Ana MG Manea Anna Zilverstand Kamil Ugurbil Sarah R Heilbronner Jan Zimmermann |
| author_facet | Ana MG Manea Anna Zilverstand Kamil Ugurbil Sarah R Heilbronner Jan Zimmermann |
| author_sort | Ana MG Manea |
| collection | DOAJ |
| description | Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magnetic resonance imaging (fMRI) performed at 10.5 T to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole-brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity (FC) topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match FC gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain. |
| first_indexed | 2024-04-12T02:23:22Z |
| format | Article |
| id | doaj.art-8b64964c2a9244ab847fd52079a41f36 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:23:22Z |
| publishDate | 2022-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-8b64964c2a9244ab847fd52079a41f362022-12-22T03:52:04ZengeLife Sciences Publications LtdeLife2050-084X2022-03-011110.7554/eLife.75540Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brainAna MG Manea0https://orcid.org/0000-0002-4786-9657Anna Zilverstand1https://orcid.org/0000-0002-4889-9700Kamil Ugurbil2Sarah R Heilbronner3Jan Zimmermann4Department of Neuroscience, University of Minnesota, Minneapolis, United States; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United StatesDepartment of Psychiatry & Behavioral Sciences , University of Minnesota, Minneapolis, United States; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, United StatesCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, United States; Department of Radiology, University of Minnesota, Minneapolis, United StatesDepartment of Neuroscience, University of Minnesota, Minneapolis, United States; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, United StatesDepartment of Neuroscience, University of Minnesota, Minneapolis, United States; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, United States; Department of Biomedical Engineering, University of Minnesota, Minneapolis, United StatesHierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magnetic resonance imaging (fMRI) performed at 10.5 T to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole-brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity (FC) topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match FC gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain.https://elifesciences.org/articles/75540neural timescalesfunctional connectivityfMRIultrahigh filedresting-statespontaneous activity |
| spellingShingle | Ana MG Manea Anna Zilverstand Kamil Ugurbil Sarah R Heilbronner Jan Zimmermann Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain eLife neural timescales functional connectivity fMRI ultrahigh filed resting-state spontaneous activity |
| title | Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain |
| title_full | Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain |
| title_fullStr | Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain |
| title_full_unstemmed | Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain |
| title_short | Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain |
| title_sort | intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain |
| topic | neural timescales functional connectivity fMRI ultrahigh filed resting-state spontaneous activity |
| url | https://elifesciences.org/articles/75540 |
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