Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes
AIM: To investigate vascular changes in different stages of glaucoma and to evaluate the role of optical coherence tomography angiography (OCTA) in the early diagnosis of glaucoma. METHODS: Glaucoma patients and healthy controls (n=29 eyes) were investigated in this cross-sectional comparative study...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-12-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2023/12/20231214.pdf |
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| author | Caner Öztürk Sirel Gür Güngör Ümit Ekşioğlu Almila Sarıgül Sezenöz Meriç Çolak |
| author_facet | Caner Öztürk Sirel Gür Güngör Ümit Ekşioğlu Almila Sarıgül Sezenöz Meriç Çolak |
| author_sort | Caner Öztürk |
| collection | DOAJ |
| description | AIM: To investigate vascular changes in different stages of glaucoma and to evaluate the role of optical coherence tomography angiography (OCTA) in the early diagnosis of glaucoma. METHODS: Glaucoma patients and healthy controls (n=29 eyes) were investigated in this cross-sectional comparative study. Glaucoma patients were grouped as ocular hypertension (n=44 eyes), preperimetric glaucoma (PPG; n=32 eyes), early glaucoma (EG; n=35 eyes), moderate stage glaucoma (MG; n=36 eyes), and advanced glaucoma (AG; n=35 eyes). Peripapillary and macular vascular densities (VDs) of all participants were compared and correlations of VDs and retinal nerve fiber layer thickness (RNFLT), ganglion cell analysis (GCA), and visual field (VF) tests were evaluated. Area under the receiver operation characteristic curves (AUC) of the peripapillary and macular VD parameters were obtained. RESULTS: VD values ??decreased with the progression of glaucoma. Most peripapillary and macular VD parameters of PPG and EG groups were lower than healthy controls (P<0.001). There was no significant difference in RNFLT between the PPG and EG groups, but most peripapillary and macular VDs were found to be lower in EG group than in PPG group (P<0.05). In most disease group, VDs were significantly correlated with OCT parameters (P<0.001) and VF index (P<0.05). There were no significant correlations between VF and RNFLT indices in the AG group, but significant correlations were found between VF and VD values (P<0.05). AUC for discriminating between healthy and glaucomatous eyes were highest in whole image peripapillary VD (AUC: 0.865, 0.929, and 0.986, respectively in EG, MG, and AG groups). CONCLUSION: OCTA can be used in the early diagnosis of glaucoma and can be useful in follow-up of the advanced disease. In cases where limitations or suspicions in structural and functional tests are present, OCTA can be used as a supportive diagnostic test, both in EG and AG. |
| first_indexed | 2024-03-10T03:57:36Z |
| format | Article |
| id | doaj.art-8b6559a39b5349e684132ea790d90a94 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-03-10T03:57:36Z |
| publishDate | 2023-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-8b6559a39b5349e684132ea790d90a942023-11-23T08:41:41ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-12-0116122018202610.18240/ijo.2023.12.1420231214Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyesCaner Öztürk0Sirel Gür Güngör1Ümit Ekşioğlu2Almila Sarıgül Sezenöz3Meriç Çolak4Caner Öztürk. Minister of Health Hitit University Erol Olçok Education and Research Hospital, Çorum 19030, Turkey. canerx6@hotmail.comDepartment of Ophthalmology, Başkent University, Faculty of Medicine, Ankara 06170, TurkeyDepartment of Ophthalmology, Başkent University, Faculty of Medicine, Ankara 06170, TurkeyDepartment of Ophthalmology, Başkent University, Faculty of Medicine, Ankara 06170, TurkeyDepartment of Biostatistics, Başkent University, Faculty of Medicine, Ankara 06300, TurkeyAIM: To investigate vascular changes in different stages of glaucoma and to evaluate the role of optical coherence tomography angiography (OCTA) in the early diagnosis of glaucoma. METHODS: Glaucoma patients and healthy controls (n=29 eyes) were investigated in this cross-sectional comparative study. Glaucoma patients were grouped as ocular hypertension (n=44 eyes), preperimetric glaucoma (PPG; n=32 eyes), early glaucoma (EG; n=35 eyes), moderate stage glaucoma (MG; n=36 eyes), and advanced glaucoma (AG; n=35 eyes). Peripapillary and macular vascular densities (VDs) of all participants were compared and correlations of VDs and retinal nerve fiber layer thickness (RNFLT), ganglion cell analysis (GCA), and visual field (VF) tests were evaluated. Area under the receiver operation characteristic curves (AUC) of the peripapillary and macular VD parameters were obtained. RESULTS: VD values ??decreased with the progression of glaucoma. Most peripapillary and macular VD parameters of PPG and EG groups were lower than healthy controls (P<0.001). There was no significant difference in RNFLT between the PPG and EG groups, but most peripapillary and macular VDs were found to be lower in EG group than in PPG group (P<0.05). In most disease group, VDs were significantly correlated with OCT parameters (P<0.001) and VF index (P<0.05). There were no significant correlations between VF and RNFLT indices in the AG group, but significant correlations were found between VF and VD values (P<0.05). AUC for discriminating between healthy and glaucomatous eyes were highest in whole image peripapillary VD (AUC: 0.865, 0.929, and 0.986, respectively in EG, MG, and AG groups). CONCLUSION: OCTA can be used in the early diagnosis of glaucoma and can be useful in follow-up of the advanced disease. In cases where limitations or suspicions in structural and functional tests are present, OCTA can be used as a supportive diagnostic test, both in EG and AG.http://ies.ijo.cn/en_publish/2023/12/20231214.pdfglaucomaoptical coherence tomography angiographyvascular densityearly diagnosis |
| spellingShingle | Caner Öztürk Sirel Gür Güngör Ümit Ekşioğlu Almila Sarıgül Sezenöz Meriç Çolak Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes International Journal of Ophthalmology glaucoma optical coherence tomography angiography vascular density early diagnosis |
| title | Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes |
| title_full | Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes |
| title_fullStr | Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes |
| title_full_unstemmed | Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes |
| title_short | Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes |
| title_sort | peripapillary and macular vascular densities in healthy ocular hypertensive and different stages of glaucomatous eyes |
| topic | glaucoma optical coherence tomography angiography vascular density early diagnosis |
| url | http://ies.ijo.cn/en_publish/2023/12/20231214.pdf |
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