Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam
Background: Limited data are available on HIV viral suppression rates among men and women on antiretroviral therapy (ART) and factors associated with HIV RNA viral load (VL) suppression in Vietnam. Methods: We conducted a cross-sectional survey of 1255 adult patients on ART for at least 1 year acros...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664020304660 |
| _version_ | 1818429875003850752 |
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| author | Suresh Rangarajan Donn J. Colby Le Truong Giang Duc Duong Bui Huu Hung Nguyen Plui Broh Tou Tran Tri Danh Ngoc Bao Chau Tran Duc Anh Nguyen Bao Tram Hoang Nguyen Vu Tuyet Nga Doan Nhat Quang Nguyen Van Phuoc Pham D.uc Giang Dao Mario Chen Yanwu Zeng Thi Thu Van Tieu My Hanh Tran Thi Hoa Le Xuan Chien Hoang Gary West |
| author_facet | Suresh Rangarajan Donn J. Colby Le Truong Giang Duc Duong Bui Huu Hung Nguyen Plui Broh Tou Tran Tri Danh Ngoc Bao Chau Tran Duc Anh Nguyen Bao Tram Hoang Nguyen Vu Tuyet Nga Doan Nhat Quang Nguyen Van Phuoc Pham D.uc Giang Dao Mario Chen Yanwu Zeng Thi Thu Van Tieu My Hanh Tran Thi Hoa Le Xuan Chien Hoang Gary West |
| author_sort | Suresh Rangarajan |
| collection | DOAJ |
| description | Background: Limited data are available on HIV viral suppression rates among men and women on antiretroviral therapy (ART) and factors associated with HIV RNA viral load (VL) suppression in Vietnam. Methods: We conducted a cross-sectional survey of 1255 adult patients on ART for at least 1 year across four provinces in Vietnam. Data collection included a standardised questionnaire, routine laboratory testing, and an HIV VL assay. Bivariate and logistic multivariate analyses were conducted to assess viral suppression rates and factors associated with unsuppressed HIV VL. Results: The median age was 34.5 years and the median time on ART was 46 months. Gender was 66% male (n=828) and 34% female (n=427). HIV viral suppression below 1000 copies/mL was 93%. Viral suppression among woman was not significantly different than among men (93.7% vs92.9%; P=0.59). On multivariate analysis, unsuppressed HIV VL was independently associated with lower CD4 cell count, social isolation, high stigma, not receiving a single-tablet daily regimen, multiple late appointments in past year, and immunological failure. Conclusion: On-treatment viral load suppression rates in Vietnam are high and already exceed the UNAIDS 90% target for viral suppression on ART. Gender does not impact viral suppression rates of patients on ART in Vietnam. Access to routine viral load testing should be improved, adherence monitoring and counselling streamlined, and ART regimens simplified to maintain viral suppression rates, as more people start ART. Psychological and social factors are also associated with unsuppressed HIV VL, necessitating treatment support interventions to address social isolation and stigma among people living with HIV in Vietnam. |
| first_indexed | 2024-12-14T15:24:27Z |
| format | Article |
| id | doaj.art-8b6596d6bc1643c99af5540676627e5c |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-12-14T15:24:27Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-8b6596d6bc1643c99af5540676627e5c2022-12-21T22:56:04ZengElsevierJournal of Virus Eradication2055-66402016-04-012294101Factors associated with HIV viral load suppression on antiretroviral therapy in VietnamSuresh Rangarajan0Donn J. Colby1Le Truong Giang2Duc Duong Bui3Huu Hung Nguyen4Plui Broh Tou5Tran Tri Danh6Ngoc Bao Chau Tran7Duc Anh Nguyen8Bao Tram Hoang Nguyen9Vu Tuyet Nga Doan10Nhat Quang Nguyen11Van Phuoc Pham12D.uc Giang Dao13Mario Chen14Yanwu Zeng15Thi Thu Van Tieu16My Hanh Tran17Thi Hoa Le18Xuan Chien Hoang19Gary West20FHI 360, Ho Chi Minh City, Vietnam; Corresponding authors: Suresh Rangarajan, MD, MSc. FHI 360 Vietnam, 1st floor, Colonnade Building, 27 Nguyen Trung Truc, District 1, Ho Chi Minh City, VietnamSEARCH, Thai Red Cross AIDS Research Center, Bangkok, Thailand; Center for Applied Research on Men and Health, Ho Chi Minh City, Vietnam; Donn J Colby, SEARCH, Thai Red Cross AIDS Research Center, 104 Rajdamri Rd, Pathumwan, Bangkok 10330, ThailandHo Chi Minh City Provincial AIDS Committee, Ho Chi Minh City, VietnamVietnam Administration for AIDS Control, Hanoi, VietnamHo Chi Minh City Provincial AIDS Committee, Ho Chi Minh City, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Hanoi, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Ho Chi Minh City, VietnamFHI 360, Hanoi, VietnamFHI 360, North Carolina, United StatesFHI 360, North Carolina, United StatesHo Chi Minh City Provincial AIDS Committee, Ho Chi Minh City, VietnamAn Giang Provincial AIDS Center, Long Xuyen, An Giang, VietnamQuang Ninh Provincial AIDS Center, Ha Long, VietnamDien Bien Provincial AIDS Center, Dien Bien, VietnamFHI 360 (retired)Background: Limited data are available on HIV viral suppression rates among men and women on antiretroviral therapy (ART) and factors associated with HIV RNA viral load (VL) suppression in Vietnam. Methods: We conducted a cross-sectional survey of 1255 adult patients on ART for at least 1 year across four provinces in Vietnam. Data collection included a standardised questionnaire, routine laboratory testing, and an HIV VL assay. Bivariate and logistic multivariate analyses were conducted to assess viral suppression rates and factors associated with unsuppressed HIV VL. Results: The median age was 34.5 years and the median time on ART was 46 months. Gender was 66% male (n=828) and 34% female (n=427). HIV viral suppression below 1000 copies/mL was 93%. Viral suppression among woman was not significantly different than among men (93.7% vs92.9%; P=0.59). On multivariate analysis, unsuppressed HIV VL was independently associated with lower CD4 cell count, social isolation, high stigma, not receiving a single-tablet daily regimen, multiple late appointments in past year, and immunological failure. Conclusion: On-treatment viral load suppression rates in Vietnam are high and already exceed the UNAIDS 90% target for viral suppression on ART. Gender does not impact viral suppression rates of patients on ART in Vietnam. Access to routine viral load testing should be improved, adherence monitoring and counselling streamlined, and ART regimens simplified to maintain viral suppression rates, as more people start ART. Psychological and social factors are also associated with unsuppressed HIV VL, necessitating treatment support interventions to address social isolation and stigma among people living with HIV in Vietnam.http://www.sciencedirect.com/science/article/pii/S2055664020304660HIVantiretroviral therapygendersingle-tablet regimenadherenceHIV viral load suppression |
| spellingShingle | Suresh Rangarajan Donn J. Colby Le Truong Giang Duc Duong Bui Huu Hung Nguyen Plui Broh Tou Tran Tri Danh Ngoc Bao Chau Tran Duc Anh Nguyen Bao Tram Hoang Nguyen Vu Tuyet Nga Doan Nhat Quang Nguyen Van Phuoc Pham D.uc Giang Dao Mario Chen Yanwu Zeng Thi Thu Van Tieu My Hanh Tran Thi Hoa Le Xuan Chien Hoang Gary West Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam Journal of Virus Eradication HIV antiretroviral therapy gender single-tablet regimen adherence HIV viral load suppression |
| title | Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam |
| title_full | Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam |
| title_fullStr | Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam |
| title_full_unstemmed | Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam |
| title_short | Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam |
| title_sort | factors associated with hiv viral load suppression on antiretroviral therapy in vietnam |
| topic | HIV antiretroviral therapy gender single-tablet regimen adherence HIV viral load suppression |
| url | http://www.sciencedirect.com/science/article/pii/S2055664020304660 |
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