Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality
BACKGROUND: Since the beginning of the COVID-19 pandemic, there have been preliminary studies worldwide, hoping to shed some light on the efficacy of convalescent plasma therapy (CPT) in the management and recovery of SARS-CoV-2-infected patients. There is a dearth of such studies, especially from...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | BLDE University Journal of Health Sciences |
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| Online Access: | http://www.bldeujournalhs.in/article.asp?issn=2468-838X;year=2023;volume=8;issue=1;spage=142;epage=149;aulast= |
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| author | Madhav Prabhu Harpreet Kour Shivani Charuhas Bhagwat Akash Ramaswamy Arathi Darshan Jayaprakash Appajigol |
| author_facet | Madhav Prabhu Harpreet Kour Shivani Charuhas Bhagwat Akash Ramaswamy Arathi Darshan Jayaprakash Appajigol |
| author_sort | Madhav Prabhu |
| collection | DOAJ |
| description | BACKGROUND: Since the beginning of the COVID-19 pandemic, there have been preliminary studies worldwide, hoping to shed some light on the efficacy of convalescent plasma therapy (CPT) in the management and recovery of SARS-CoV-2-infected patients. There is a dearth of such studies, especially from one of the world's second-worst hit country-India. This study aims to determine the effects of CPT on the clinical and biochemical profile, and overall mortality of patients suffering from moderate-to-severe SARS-CoV-2 infection.
MATERIALS AND METHODS: After random selection of inpatients with COVID-19 disease, patients were matched for various characteristics and allotted into cases and control groups. This was done keeping a 1:2 ratio for cases and controls. Cerebral palsy (CP) therapy was administered to only cases, and these groups were compared. P < 0.05 was considered statistically significant.
RESULTS AND CONCLUSIONS: Totally, 141 patients – 47 cases and 94 controls – were compared for the efficacy of CPT on clinical and biochemical profiles along with mortality benefit. It was found that CP therapy provided no significant morbidity and mortality benefit. |
| first_indexed | 2024-03-12T22:33:40Z |
| format | Article |
| id | doaj.art-8b66073bc9024982a2ed8e90d234cec2 |
| institution | Directory Open Access Journal |
| issn | 2468-838X 2456-1975 |
| language | English |
| last_indexed | 2024-03-12T22:33:40Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | BLDE University Journal of Health Sciences |
| spelling | doaj.art-8b66073bc9024982a2ed8e90d234cec22023-07-21T14:28:45ZengWolters Kluwer Medknow PublicationsBLDE University Journal of Health Sciences2468-838X2456-19752023-01-018114214910.4103/bjhs.bjhs_171_22Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortalityMadhav PrabhuHarpreet KourShivani Charuhas BhagwatAkash RamaswamyArathi DarshanJayaprakash AppajigolBACKGROUND: Since the beginning of the COVID-19 pandemic, there have been preliminary studies worldwide, hoping to shed some light on the efficacy of convalescent plasma therapy (CPT) in the management and recovery of SARS-CoV-2-infected patients. There is a dearth of such studies, especially from one of the world's second-worst hit country-India. This study aims to determine the effects of CPT on the clinical and biochemical profile, and overall mortality of patients suffering from moderate-to-severe SARS-CoV-2 infection. MATERIALS AND METHODS: After random selection of inpatients with COVID-19 disease, patients were matched for various characteristics and allotted into cases and control groups. This was done keeping a 1:2 ratio for cases and controls. Cerebral palsy (CP) therapy was administered to only cases, and these groups were compared. P < 0.05 was considered statistically significant. RESULTS AND CONCLUSIONS: Totally, 141 patients – 47 cases and 94 controls – were compared for the efficacy of CPT on clinical and biochemical profiles along with mortality benefit. It was found that CP therapy provided no significant morbidity and mortality benefit.http://www.bldeujournalhs.in/article.asp?issn=2468-838X;year=2023;volume=8;issue=1;spage=142;epage=149;aulast=biochemical profileconvalescent plasma therapycovid-19morbiditymortality |
| spellingShingle | Madhav Prabhu Harpreet Kour Shivani Charuhas Bhagwat Akash Ramaswamy Arathi Darshan Jayaprakash Appajigol Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality BLDE University Journal of Health Sciences biochemical profile convalescent plasma therapy covid-19 morbidity mortality |
| title | Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality |
| title_full | Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality |
| title_fullStr | Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality |
| title_full_unstemmed | Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality |
| title_short | Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality |
| title_sort | convalescent plasma therapy in the management of covid 19 patients and its effect on morbidity and mortality |
| topic | biochemical profile convalescent plasma therapy covid-19 morbidity mortality |
| url | http://www.bldeujournalhs.in/article.asp?issn=2468-838X;year=2023;volume=8;issue=1;spage=142;epage=149;aulast= |
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