Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!
Introduction: Healthcare-associated infections are an important cause of morbidity and mortality, are among the most common adverse events in healthcare, and of them, pneumonia is the most commonly reported. Our objective was to evaluate the incidence and clinical outcome of respiratory viruses in h...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00168/full |
| _version_ | 1819022819659350016 |
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| author | Margarita Torres-García Brenda Berenice Pérez Méndez José Luis Sánchez Huerta Mónica Villa Guillén Virydiana Rementería Vazquez Arturo Daniel Castro Diaz Briceida López Martinez Almudena Laris González Rodolfo Norberto Jiménez-Juárez Rodolfo Norberto Jiménez-Juárez Daniela de la Rosa-Zamboni |
| author_facet | Margarita Torres-García Brenda Berenice Pérez Méndez José Luis Sánchez Huerta Mónica Villa Guillén Virydiana Rementería Vazquez Arturo Daniel Castro Diaz Briceida López Martinez Almudena Laris González Rodolfo Norberto Jiménez-Juárez Rodolfo Norberto Jiménez-Juárez Daniela de la Rosa-Zamboni |
| author_sort | Margarita Torres-García |
| collection | DOAJ |
| description | Introduction: Healthcare-associated infections are an important cause of morbidity and mortality, are among the most common adverse events in healthcare, and of them, pneumonia is the most commonly reported. Our objective was to evaluate the incidence and clinical outcome of respiratory viruses in hospital-acquired pneumonia (HAP).Methods: This was a prospective cohort study, include patients aged between 0 and 18 who fulfilled Centers for Diseases Control and Prevention (CDC) criteria for HAP. Demographic and clinical data were obtained, and a nasopharyngeal swab specimen was taken for the detection of respiratory viruses. All included patients were monitored until discharge to collect data on the need for mechanical ventilation, intensive care unit (ICU) admission, and mortality. All-cause 30-day mortality was also ascertained.Results: Four thousand three hundred twenty-seven patients were followed for 42,658 patient-days and 5,150 ventilator-days. Eighty-eight patients (2.03%) met the CDC criteria for HAP, 63 patients were included, and clinical and epidemiological characteristics showed no statistically significant differences between patients with virus associated healthcare-associated pneumonia (VAHAP) and those with non-viral healthcare-associated pneumonia (NVHAP). At least one respiratory virus was detected in 65% [95% CI (53–77)] of episodes of HAP, with a single viral pathogen observed in 53.9% and coinfection with 2 viruses in 11.1% of cases. The outcome in terms of ICU admission, mechanical ventilation and the 30-day mortality did not show a significant difference between groups.Conclusions: In two-thirds of the patients a respiratory virus was identified. There was no difference in mortality or the rest of the clinical outcome variables. About half of the patients required mechanical ventilation and 10% died, which emphasizes the importance of considering these pathogens in nosocomial infections, since their identification can influence the decrease in hospital costs and be taken into account in infection control policies. |
| first_indexed | 2024-12-21T04:29:04Z |
| format | Article |
| id | doaj.art-8b670288bce948cdbc25a70cc82d82a7 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-21T04:29:04Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-8b670288bce948cdbc25a70cc82d82a72022-12-21T19:15:59ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-05-01710.3389/fped.2019.00168453640Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!Margarita Torres-García0Brenda Berenice Pérez Méndez1José Luis Sánchez Huerta2Mónica Villa Guillén3Virydiana Rementería Vazquez4Arturo Daniel Castro Diaz5Briceida López Martinez6Almudena Laris González7Rodolfo Norberto Jiménez-Juárez8Rodolfo Norberto Jiménez-Juárez9Daniela de la Rosa-Zamboni10Epidemiology Department, Federico Gómez Children's Hospital of Mexico, Mexico City, MexicoInfectious Diseases Department, Federico Gómez Children's Hospital of Mexico, Mexico City, MexicoMolecular Biology Department, Federico Gómez Children's Hospital of Mexico, Mexico City, MexicoFederico Gomez Children's Hospital of Mexico, Mexico City, MexicoEducation Department, Federico Gomez Children's Hospital of Mexico, Mexico City, MexicoFederico Gomez Children's Hospital of Mexico, Mexico City, MexicoDiagnostic Auxiliary Services, Federico Gomez Children's Hospital of Mexico, Mexico City, MexicoEpidemiology Department, Federico Gómez Children's Hospital of Mexico, Mexico City, MexicoInfectious Diseases Department, Federico Gómez Children's Hospital of Mexico, Mexico City, MexicoDepartment of Pediatrics, National Medical Center La Raza, Infectious Diseases Hospital, Mexican Institute of Social Security, Mexico City, MexicoEpidemiology Department, Federico Gómez Children's Hospital of Mexico, Mexico City, MexicoIntroduction: Healthcare-associated infections are an important cause of morbidity and mortality, are among the most common adverse events in healthcare, and of them, pneumonia is the most commonly reported. Our objective was to evaluate the incidence and clinical outcome of respiratory viruses in hospital-acquired pneumonia (HAP).Methods: This was a prospective cohort study, include patients aged between 0 and 18 who fulfilled Centers for Diseases Control and Prevention (CDC) criteria for HAP. Demographic and clinical data were obtained, and a nasopharyngeal swab specimen was taken for the detection of respiratory viruses. All included patients were monitored until discharge to collect data on the need for mechanical ventilation, intensive care unit (ICU) admission, and mortality. All-cause 30-day mortality was also ascertained.Results: Four thousand three hundred twenty-seven patients were followed for 42,658 patient-days and 5,150 ventilator-days. Eighty-eight patients (2.03%) met the CDC criteria for HAP, 63 patients were included, and clinical and epidemiological characteristics showed no statistically significant differences between patients with virus associated healthcare-associated pneumonia (VAHAP) and those with non-viral healthcare-associated pneumonia (NVHAP). At least one respiratory virus was detected in 65% [95% CI (53–77)] of episodes of HAP, with a single viral pathogen observed in 53.9% and coinfection with 2 viruses in 11.1% of cases. The outcome in terms of ICU admission, mechanical ventilation and the 30-day mortality did not show a significant difference between groups.Conclusions: In two-thirds of the patients a respiratory virus was identified. There was no difference in mortality or the rest of the clinical outcome variables. About half of the patients required mechanical ventilation and 10% died, which emphasizes the importance of considering these pathogens in nosocomial infections, since their identification can influence the decrease in hospital costs and be taken into account in infection control policies.https://www.frontiersin.org/article/10.3389/fped.2019.00168/fullhospital-acquired pneumoniaviral pneumoniarespiratory virusesnosocomial infectionshealthcare-associated infections |
| spellingShingle | Margarita Torres-García Brenda Berenice Pérez Méndez José Luis Sánchez Huerta Mónica Villa Guillén Virydiana Rementería Vazquez Arturo Daniel Castro Diaz Briceida López Martinez Almudena Laris González Rodolfo Norberto Jiménez-Juárez Rodolfo Norberto Jiménez-Juárez Daniela de la Rosa-Zamboni Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses! Frontiers in Pediatrics hospital-acquired pneumonia viral pneumonia respiratory viruses nosocomial infections healthcare-associated infections |
| title | Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses! |
| title_full | Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses! |
| title_fullStr | Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses! |
| title_full_unstemmed | Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses! |
| title_short | Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses! |
| title_sort | healthcare associated pneumonia don t forget about respiratory viruses |
| topic | hospital-acquired pneumonia viral pneumonia respiratory viruses nosocomial infections healthcare-associated infections |
| url | https://www.frontiersin.org/article/10.3389/fped.2019.00168/full |
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