Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study
<p>Abstract</p> <p>Background</p> <p>Polymorphisms in Epidermal Growth Factor Receptor (<it>EGFR</it>) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the associat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2007-10-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/7/199 |
| _version_ | 1811299040177946624 |
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| author | Kim Young-Chul Mo Kang Young Ho Kim Chang Cha Sung Kam Sin Lee Won Kim Kyung Ha Park Sun Choi Jin Han Sung Jung Tae Park Jae |
| author_facet | Kim Young-Chul Mo Kang Young Ho Kim Chang Cha Sung Kam Sin Lee Won Kim Kyung Ha Park Sun Choi Jin Han Sung Jung Tae Park Jae |
| author_sort | Kim Young-Chul |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Polymorphisms in Epidermal Growth Factor Receptor (<it>EGFR</it>) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the association between polymorphisms in the <it>EGFR </it>gene and the risk of lung cancer in a Korean population.</p> <p>Methods</p> <p>We first examined the frequencies of 39 candidate polymorphisms in the <it>EGFR </it>gene in 27 healthy Korean individuals. After then, we genotyped five polymorphisms (127378C>T, 142285G>A, 162093G>A, 181946C>T and 187114T>C) that have variant allele frequencies greater than 10%, in 582 lung cancer patients and in 582 healthy controls.</p> <p>Results</p> <p>Of the 5 polymorphisms, the 181946C>T genotype distribution was significantly different between the cases and controls (<it>P </it>= 0.04). Compared with the 181946 CC + CT genotype, the 181946 TT genotype was associated with a significantly decreased risk of lung cancer (adjusted OR = 0.63, 95% CI = 0.45–0.88, <it>P </it>= 0.007). When the analyses were stratified by smoking status, the protective effect of the TT genotype was statistically significant in ever-smokers (adjusted OR = 0.59, 95% CI = 0.41–0.86, <it>P </it>= 0.007), but not in never-smokers (adjusted OR = 0.89, 95% CI = 0.45–1.75, <it>P </it>= 0.73; <it>P </it>= 0.08, test for homogeneity). Consistent with the results of the genotyping analysis, the CGGCT haplotype with the 181946C allele was associated with a significantly increased risk of lung cancer compared to the CGGTT haplotype carrying the 181946T allele (adjusted OR = 1.50, 95% CI = 1.09–2.07, <it>P </it>= 0.012 and Bonferroni corrected <it>P</it>-value = 0.048).</p> <p>Conclusion</p> <p>These results suggest that the <it>EGFR </it>polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer.</p> |
| first_indexed | 2024-04-13T06:30:11Z |
| format | Article |
| id | doaj.art-8b6aa7a6252c47729ceddf43f9eb1542 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T06:30:11Z |
| publishDate | 2007-10-01 |
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| series | BMC Cancer |
| spelling | doaj.art-8b6aa7a6252c47729ceddf43f9eb15422022-12-22T02:58:13ZengBMCBMC Cancer1471-24072007-10-017119910.1186/1471-2407-7-199Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control studyKim Young-ChulMo Kang YoungHo Kim ChangCha SungKam SinLee WonKim KyungHa Park SunChoi JinHan SungJung TaePark Jae<p>Abstract</p> <p>Background</p> <p>Polymorphisms in Epidermal Growth Factor Receptor (<it>EGFR</it>) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the association between polymorphisms in the <it>EGFR </it>gene and the risk of lung cancer in a Korean population.</p> <p>Methods</p> <p>We first examined the frequencies of 39 candidate polymorphisms in the <it>EGFR </it>gene in 27 healthy Korean individuals. After then, we genotyped five polymorphisms (127378C>T, 142285G>A, 162093G>A, 181946C>T and 187114T>C) that have variant allele frequencies greater than 10%, in 582 lung cancer patients and in 582 healthy controls.</p> <p>Results</p> <p>Of the 5 polymorphisms, the 181946C>T genotype distribution was significantly different between the cases and controls (<it>P </it>= 0.04). Compared with the 181946 CC + CT genotype, the 181946 TT genotype was associated with a significantly decreased risk of lung cancer (adjusted OR = 0.63, 95% CI = 0.45–0.88, <it>P </it>= 0.007). When the analyses were stratified by smoking status, the protective effect of the TT genotype was statistically significant in ever-smokers (adjusted OR = 0.59, 95% CI = 0.41–0.86, <it>P </it>= 0.007), but not in never-smokers (adjusted OR = 0.89, 95% CI = 0.45–1.75, <it>P </it>= 0.73; <it>P </it>= 0.08, test for homogeneity). Consistent with the results of the genotyping analysis, the CGGCT haplotype with the 181946C allele was associated with a significantly increased risk of lung cancer compared to the CGGTT haplotype carrying the 181946T allele (adjusted OR = 1.50, 95% CI = 1.09–2.07, <it>P </it>= 0.012 and Bonferroni corrected <it>P</it>-value = 0.048).</p> <p>Conclusion</p> <p>These results suggest that the <it>EGFR </it>polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer.</p>http://www.biomedcentral.com/1471-2407/7/199 |
| spellingShingle | Kim Young-Chul Mo Kang Young Ho Kim Chang Cha Sung Kam Sin Lee Won Kim Kyung Ha Park Sun Choi Jin Han Sung Jung Tae Park Jae Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study BMC Cancer |
| title | Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study |
| title_full | Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study |
| title_fullStr | Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study |
| title_full_unstemmed | Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study |
| title_short | Polymorphisms in the <it>epidermal growth factor receptor </it>gene and the risk of primary lung cancer: a case-control study |
| title_sort | polymorphisms in the it epidermal growth factor receptor it gene and the risk of primary lung cancer a case control study |
| url | http://www.biomedcentral.com/1471-2407/7/199 |
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