Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1α Axis

Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1α Axis

Aims: Hypertension increases the risk of heart disease. Hallmark features of hypertensive heart disease is sympathoexcitation and cardiac mitochondrial abnormality. However, the molecular mechanisms for specifically neurally mediated mitochondrial abnormality and subsequent cardiac dysfunction are u...

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Bibliographic Details
Main Authors: Shyam S. Nandi, Kenichi Katsurada, Sushil K. Mahata, Kaushik P. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Physiology
Subjects:
hypertension
mitochondrial damage
cardiac hypertrophy
cardiac fibrosis
HIF-1α
miR-18a-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.718982/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.718982/full

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