Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization
Abstract The association between rosacea and inflammatory bowel disease (IBD) has been studied in previous observational studies. It is unclear, however, whether the association is causal or not. Independent genetic variants for IBD were chosen as instruments from published Genome-wide association s...
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Nature Portfolio
2023-09-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-42073-6 |
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author | Min Li Si Xian He Yuan Xiong He Xiao Han Hu Zhou Zhou |
author_facet | Min Li Si Xian He Yuan Xiong He Xiao Han Hu Zhou Zhou |
author_sort | Min Li |
collection | DOAJ |
description | Abstract The association between rosacea and inflammatory bowel disease (IBD) has been studied in previous observational studies. It is unclear, however, whether the association is causal or not. Independent genetic variants for IBD were chosen as instruments from published Genome-wide association studies (GWAS) studies involving 38,155 cases with an IBD diagnosis and 48,485 controls in order to investigate the causal effect of IBD on rosacea. Summarized data for rosacea were gathered from various GWAS studies that included 1195 cases and 211,139 controls without rosacea. Reverse-direction Mendelian randomization (MR) analysis was done to investigate the relationship between genetically proxied rosacea and IBD. With the use of the inverse variance-weighted (IVW), MR-Egger, and weighted median approaches, a 2-sample Mendelian randomization study was carried out. Analysis of heterogeneity and sensitivity was performed to examine the pleiotropy and robustness of effect estimates. The forward-direction of the MR study was to reveal that genetic predisposition to IBD including its two main subtypes: Crohn’s disease (CD) and ulcerative colitis (UC) was associated with an increased risk of rosacea. The reverse-direction MR analyses did not demonstrate that a genetic predisposition to rosacea was associated with total IBD, UC and CD. Our findings provided evidence for a causal impact of IBD, UC, and CD on rosacea, but not vice versa. The elevated incidence of rosacea in patients with IBD should be recognized by doctors to make an early diagnosis and initiate specialized therapy. |
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spelling | doaj.art-8b6b6b2afede4fff9aa08617df11eee62023-11-19T12:56:17ZengNature PortfolioScientific Reports2045-23222023-09-011311910.1038/s41598-023-42073-6Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomizationMin Li0Si Xian He1Yuan Xiong He2Xiao Han Hu3Zhou Zhou4Department of Dermatology, People’s Liberation Army The General Hospital of Western Theater CommandDepartment of Dermatology, People’s Liberation Army The General Hospital of Western Theater CommandDepartment of Dermatology, People’s Liberation Army The General Hospital of Western Theater CommandDepartment of Dermatology, People’s Liberation Army The General Hospital of Western Theater CommandDepartment of Dermatology, People’s Liberation Army The General Hospital of Western Theater CommandAbstract The association between rosacea and inflammatory bowel disease (IBD) has been studied in previous observational studies. It is unclear, however, whether the association is causal or not. Independent genetic variants for IBD were chosen as instruments from published Genome-wide association studies (GWAS) studies involving 38,155 cases with an IBD diagnosis and 48,485 controls in order to investigate the causal effect of IBD on rosacea. Summarized data for rosacea were gathered from various GWAS studies that included 1195 cases and 211,139 controls without rosacea. Reverse-direction Mendelian randomization (MR) analysis was done to investigate the relationship between genetically proxied rosacea and IBD. With the use of the inverse variance-weighted (IVW), MR-Egger, and weighted median approaches, a 2-sample Mendelian randomization study was carried out. Analysis of heterogeneity and sensitivity was performed to examine the pleiotropy and robustness of effect estimates. The forward-direction of the MR study was to reveal that genetic predisposition to IBD including its two main subtypes: Crohn’s disease (CD) and ulcerative colitis (UC) was associated with an increased risk of rosacea. The reverse-direction MR analyses did not demonstrate that a genetic predisposition to rosacea was associated with total IBD, UC and CD. Our findings provided evidence for a causal impact of IBD, UC, and CD on rosacea, but not vice versa. The elevated incidence of rosacea in patients with IBD should be recognized by doctors to make an early diagnosis and initiate specialized therapy.https://doi.org/10.1038/s41598-023-42073-6 |
spellingShingle | Min Li Si Xian He Yuan Xiong He Xiao Han Hu Zhou Zhou Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization Scientific Reports |
title | Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization |
title_full | Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization |
title_fullStr | Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization |
title_full_unstemmed | Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization |
title_short | Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization |
title_sort | detecting potential causal relationship between inflammatory bowel disease and rosacea using bi directional mendelian randomization |
url | https://doi.org/10.1038/s41598-023-42073-6 |
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