Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity
Background: The effectiveness of the COVID-19 vaccine may differ in hemodialysis patients. The aim of this prospective multicenter study was to determine the degree of serological response to the SARS-CoV-2 vaccine in the population of dialysis patients and its association with later SARS-CoV-2 infe...
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| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antibodies |
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| Online Access: | https://www.mdpi.com/2073-4468/12/2/37 |
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| author | Vedran Premuzic Ranko Stevanovic Tatjana Vilibic-Cavlek Maja Sirovica Sara Stalman Maja Bogdanic Denis Zilic Dario Nakic Danijela Santini Dusevic Marina Vojkovic Jerko Barbic Ivan Durlen Zeljka Grdan Drasko Pavlovic Boris Kudumija Sinisa Sefer Davor Griparic Dunja Rogic Marija Bubas Krunoslav Capak Bojan Jelakovic |
| author_facet | Vedran Premuzic Ranko Stevanovic Tatjana Vilibic-Cavlek Maja Sirovica Sara Stalman Maja Bogdanic Denis Zilic Dario Nakic Danijela Santini Dusevic Marina Vojkovic Jerko Barbic Ivan Durlen Zeljka Grdan Drasko Pavlovic Boris Kudumija Sinisa Sefer Davor Griparic Dunja Rogic Marija Bubas Krunoslav Capak Bojan Jelakovic |
| author_sort | Vedran Premuzic |
| collection | DOAJ |
| description | Background: The effectiveness of the COVID-19 vaccine may differ in hemodialysis patients. The aim of this prospective multicenter study was to determine the degree of serological response to the SARS-CoV-2 vaccine in the population of dialysis patients and its association with later SARS-CoV-2 infections. Methods: A blood sample was taken for the determination of COVID-19 serological status (IgG antibodies) in 706 dialysis patients 16 weeks after vaccination with the second dose (Pfizer-BioNTech). Results: Only 314 (44.5%) hemodialyzed patients had a satisfactory response to the COVID-19 vaccine. Eighty-two patients (11.6%) had a borderline response, while 310 patients (43.9%) had an unsatisfactory (negative) post-vaccinal antibody titer. A longer dialysis vintage had an increased odds ratio (OR) of 1.01 for the occurrence of COVID-19 positivity after vaccination. In the group of subsequently positive patients, 28 patients (13.6%) died from complications of COVID-19. We have found differences in mean survival time between patients with and without appropriate responses to vaccination in favor of patients with a satisfactory serological response. Conclusions: The results showed that the dialysis population will not have the same serological response to the vaccine as the general population. The majority of dialysis patients did not develop a severe clinical picture or die at the time of positivity for COVID-19. |
| first_indexed | 2024-03-11T02:50:47Z |
| format | Article |
| id | doaj.art-8b6c28284e804e84b8d7e7df05c9daf4 |
| institution | Directory Open Access Journal |
| issn | 2073-4468 |
| language | English |
| last_indexed | 2024-03-11T02:50:47Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj.art-8b6c28284e804e84b8d7e7df05c9daf42023-11-18T09:01:55ZengMDPI AGAntibodies2073-44682023-05-011223710.3390/antib12020037Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 PositivityVedran Premuzic0Ranko Stevanovic1Tatjana Vilibic-Cavlek2Maja Sirovica3Sara Stalman4Maja Bogdanic5Denis Zilic6Dario Nakic7Danijela Santini Dusevic8Marina Vojkovic9Jerko Barbic10Ivan Durlen11Zeljka Grdan12Drasko Pavlovic13Boris Kudumija14Sinisa Sefer15Davor Griparic16Dunja Rogic17Marija Bubas18Krunoslav Capak19Bojan Jelakovic20Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, 10000 Zagreb, CroatiaCroatian Institute of Public Health, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaCroatian Institute of Public Health, 10000 Zagreb, CroatiaAxon Lab d.o.o., 10000 Zagreb, CroatiaDepartment of Nephrology and Dialysis, General Hospital Zadar, 23000 Zadar, CroatiaDepartment of Nephrology and Dialysis, General Hospital Zadar, 23000 Zadar, CroatiaDepartment of Nephrology and Dialysis, General Hospital Zadar, 23000 Zadar, CroatiaDepartment of Nephrology, Dialysis and Transplantation, Clinical Hospital Center Osijek, 31000 Osijek, CroatiaDepartment of Nephrology and Dialysis, University Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Nephrology, Clinical Hospital Varazdin, 42000 Varazdin, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaPoliclinic for Internal Medicine and Dialysis B. Braun Avitum, 10000 Zagreb, CroatiaDepartment of Nephrology and Dialysis, University Clinical Hospital Centre “Sestre Milosrdnice”, 10000 Zagreb, CroatiaPoliclinic for Dialysis Fresenius Sveti Duh 2, 10000 Zagreb, CroatiaClinical Institute for Laboratory Diagnostics, University Hospital Center Zagreb, 10000 Zagreb, CroatiaCroatian Institute of Public Health, 10000 Zagreb, CroatiaCroatian Institute of Public Health, 10000 Zagreb, CroatiaDepartment of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, 10000 Zagreb, CroatiaBackground: The effectiveness of the COVID-19 vaccine may differ in hemodialysis patients. The aim of this prospective multicenter study was to determine the degree of serological response to the SARS-CoV-2 vaccine in the population of dialysis patients and its association with later SARS-CoV-2 infections. Methods: A blood sample was taken for the determination of COVID-19 serological status (IgG antibodies) in 706 dialysis patients 16 weeks after vaccination with the second dose (Pfizer-BioNTech). Results: Only 314 (44.5%) hemodialyzed patients had a satisfactory response to the COVID-19 vaccine. Eighty-two patients (11.6%) had a borderline response, while 310 patients (43.9%) had an unsatisfactory (negative) post-vaccinal antibody titer. A longer dialysis vintage had an increased odds ratio (OR) of 1.01 for the occurrence of COVID-19 positivity after vaccination. In the group of subsequently positive patients, 28 patients (13.6%) died from complications of COVID-19. We have found differences in mean survival time between patients with and without appropriate responses to vaccination in favor of patients with a satisfactory serological response. Conclusions: The results showed that the dialysis population will not have the same serological response to the vaccine as the general population. The majority of dialysis patients did not develop a severe clinical picture or die at the time of positivity for COVID-19.https://www.mdpi.com/2073-4468/12/2/37serological responseSARS-CoV-2hemodialysisvaccinationCOVID-19 |
| spellingShingle | Vedran Premuzic Ranko Stevanovic Tatjana Vilibic-Cavlek Maja Sirovica Sara Stalman Maja Bogdanic Denis Zilic Dario Nakic Danijela Santini Dusevic Marina Vojkovic Jerko Barbic Ivan Durlen Zeljka Grdan Drasko Pavlovic Boris Kudumija Sinisa Sefer Davor Griparic Dunja Rogic Marija Bubas Krunoslav Capak Bojan Jelakovic Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity Antibodies serological response SARS-CoV-2 hemodialysis vaccination COVID-19 |
| title | Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity |
| title_full | Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity |
| title_fullStr | Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity |
| title_full_unstemmed | Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity |
| title_short | Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity |
| title_sort | serological response to sars cov 2 vaccine in hemodialyzed patients and the association with later covid 19 positivity |
| topic | serological response SARS-CoV-2 hemodialysis vaccination COVID-19 |
| url | https://www.mdpi.com/2073-4468/12/2/37 |
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