Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS
Background: Transcranial magnetic stimulation (TMS) is a widely used technique for the noninvasive assessment and manipulation of brain activity and behavior. Although extensively used for research and clinical purposes, recent studies have questioned the reliability of TMS findings because of the h...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922008357 |
| _version_ | 1811178643912654848 |
|---|---|
| author | Arianna Menardi Recep A. Ozdemir Davide Momi Ehsan Tadayon Pierre Boucher Antonino Vallesi Alvaro Pascual-Leone Mouhsin M. Shafi Emiliano santarnecchi |
| author_facet | Arianna Menardi Recep A. Ozdemir Davide Momi Ehsan Tadayon Pierre Boucher Antonino Vallesi Alvaro Pascual-Leone Mouhsin M. Shafi Emiliano santarnecchi |
| author_sort | Arianna Menardi |
| collection | DOAJ |
| description | Background: Transcranial magnetic stimulation (TMS) is a widely used technique for the noninvasive assessment and manipulation of brain activity and behavior. Although extensively used for research and clinical purposes, recent studies have questioned the reliability of TMS findings because of the high inter-individual variability that has been observed. Objective: In this study, we compared the efficacy and reliability of different targeting scenarios on the TMS-evoked response. Methods: 24 subjects underwent a single pulse stimulation protocol over two parietal nodes belonging to the Dorsal Attention (DAN) and Default Mode (DMN) Networks respectively. Across visits, the stimulated target for both networks was chosen either based on group-derived networks’ maps or personalized network topography based on individual anatomy and functional profile. All stimulation visits were conducted twice, one month apart, during concomitant electroencephalography recording. Results: At the network level, we did not observe significant differences in the TMS-evoked response between targeting conditions. However, reliable patterns of activity were observed— for both networks tested— following the individualized targeting approach. When the same analyses were carried out at the electrode space level, evidence of reliable patterns was observed following the individualized stimulation of the DAN, but not of the DMN. Conclusions: Our findings suggest that individualization of stimulation sites might ensure reliability of the evoked TMS-response across visits. Furthermore, individualized stimulation sites appear to be of foremost importance in highly variable, high order task-positive networks, such as the DAN. |
| first_indexed | 2024-04-11T06:21:57Z |
| format | Article |
| id | doaj.art-8b6dc77ee499473384587cae02a8ae58 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-11T06:21:57Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-8b6dc77ee499473384587cae02a8ae582022-12-22T04:40:32ZengElsevierNeuroImage1095-95722022-12-01264119714Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMSArianna Menardi0Recep A. Ozdemir1Davide Momi2Ehsan Tadayon3Pierre Boucher4Antonino Vallesi5Alvaro Pascual-Leone6Mouhsin M. Shafi7Emiliano santarnecchi8Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neuroscience & Padova Neuroscience Center, University of Padova, Padova, Italy; Corresponding authors: Arianna Menardi, Department of Neuroscience & Padova Neuroscience Center, University of Padova, Via G. Orus, 2, Padova, Italy 35129.Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USABerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; Department of Neuroscience, Imaging and Clinical Sciences, University “G. d'Annunzio”, Chieti, ItalyBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USABerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USADepartment of Neuroscience & Padova Neuroscience Center, University of Padova, Padova, ItalyDepartment of Neurology, Harvard Medical School, Boston, MA, USA; Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Rosindale, MA, USA; Guttmann Brain Health Institut, Barcelona, SpainBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USAPrecision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Emiliano Santarnecchi, Department of Radiology, Gordon Center for Medical Imaging, Harvard Medical School, 55 Fruit Street, Boston, MA 02114.Background: Transcranial magnetic stimulation (TMS) is a widely used technique for the noninvasive assessment and manipulation of brain activity and behavior. Although extensively used for research and clinical purposes, recent studies have questioned the reliability of TMS findings because of the high inter-individual variability that has been observed. Objective: In this study, we compared the efficacy and reliability of different targeting scenarios on the TMS-evoked response. Methods: 24 subjects underwent a single pulse stimulation protocol over two parietal nodes belonging to the Dorsal Attention (DAN) and Default Mode (DMN) Networks respectively. Across visits, the stimulated target for both networks was chosen either based on group-derived networks’ maps or personalized network topography based on individual anatomy and functional profile. All stimulation visits were conducted twice, one month apart, during concomitant electroencephalography recording. Results: At the network level, we did not observe significant differences in the TMS-evoked response between targeting conditions. However, reliable patterns of activity were observed— for both networks tested— following the individualized targeting approach. When the same analyses were carried out at the electrode space level, evidence of reliable patterns was observed following the individualized stimulation of the DAN, but not of the DMN. Conclusions: Our findings suggest that individualization of stimulation sites might ensure reliability of the evoked TMS-response across visits. Furthermore, individualized stimulation sites appear to be of foremost importance in highly variable, high order task-positive networks, such as the DAN.http://www.sciencedirect.com/science/article/pii/S1053811922008357Transcranial magnetic stimulationReliabilityPersonalized interventionsDorsal attention networkDefault Mode Network |
| spellingShingle | Arianna Menardi Recep A. Ozdemir Davide Momi Ehsan Tadayon Pierre Boucher Antonino Vallesi Alvaro Pascual-Leone Mouhsin M. Shafi Emiliano santarnecchi Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS NeuroImage Transcranial magnetic stimulation Reliability Personalized interventions Dorsal attention network Default Mode Network |
| title | Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS |
| title_full | Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS |
| title_fullStr | Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS |
| title_full_unstemmed | Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS |
| title_short | Effect of group-based vs individualized stimulation site selection on reliability of network-targeted TMS |
| title_sort | effect of group based vs individualized stimulation site selection on reliability of network targeted tms |
| topic | Transcranial magnetic stimulation Reliability Personalized interventions Dorsal attention network Default Mode Network |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922008357 |
| work_keys_str_mv | AT ariannamenardi effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT recepaozdemir effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT davidemomi effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT ehsantadayon effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT pierreboucher effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT antoninovallesi effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT alvaropascualleone effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT mouhsinmshafi effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms AT emilianosantarnecchi effectofgroupbasedvsindividualizedstimulationsiteselectiononreliabilityofnetworktargetedtms |