Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome
Objective: To test whether women with metabolic syndrome (MS) have impairments in the on- and off-transients during an incremental test and to study whether any of the MS components are independently associated with the observed responses.Research Design and Methods: Thirty-six women aged 35–55 year...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00542/full |
| _version_ | 1811226082318221312 |
|---|---|
| author | Lucas R. B. E. Silva Antonio R. Zamunér Paulo Gentil Paulo Gentil Fagner M. Alves Acácia G. F. Leal Viviane Soares Viviane Soares Maria S. Silva Maria S. Silva Marcus F. Vieira Marcus F. Vieira Karina Simões Gustavo R. Pedrino Ana C. S. Rebelo Ana C. S. Rebelo |
| author_facet | Lucas R. B. E. Silva Antonio R. Zamunér Paulo Gentil Paulo Gentil Fagner M. Alves Acácia G. F. Leal Viviane Soares Viviane Soares Maria S. Silva Maria S. Silva Marcus F. Vieira Marcus F. Vieira Karina Simões Gustavo R. Pedrino Ana C. S. Rebelo Ana C. S. Rebelo |
| author_sort | Lucas R. B. E. Silva |
| collection | DOAJ |
| description | Objective: To test whether women with metabolic syndrome (MS) have impairments in the on- and off-transients during an incremental test and to study whether any of the MS components are independently associated with the observed responses.Research Design and Methods: Thirty-six women aged 35–55 years were divided into a group with MS (MSG, n = 19) and a control group (CG, n = 17). R-R intervals (RRi) and heart rate variability (HRV) were calculated on a beat-to-beat basis and the heart rate (HR) at the on- and off-transient were analyzed during an incremental cardiopulmonary exercise test (CPET).Results: MSG showed lower aerobic capacity and lower parasympathetic cardiac modulation at rest compared with CG. HR values in on-transient phase were significantly lower in MSG compared with CG. The exponential amplitudes “amp” and the parameters “τ” [speed of heart rate recovery (HRR)] were lower in MSG. MSG exhibited higher HR values in comparison to CG during the off-transient indicating a slower HRR. In MSG, there was an inverse and significant correlation between fasting plasma vs. ΔF and glucose vs. exponential “τ” of HRR dynamics.Conclusion: MS is associated with poor heart rate kinetics. The altered HR kinetics seems to be related to alterations in cardiac parasympathetic modulation, and glucose metabolism seems to be the major determinant. |
| first_indexed | 2024-04-12T09:18:22Z |
| format | Article |
| id | doaj.art-8b6de715870a415c9cba420fcad38bff |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T09:18:22Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8b6de715870a415c9cba420fcad38bff2022-12-22T03:38:45ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-07-01810.3389/fphys.2017.00542280073Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic SyndromeLucas R. B. E. Silva0Antonio R. Zamunér1Paulo Gentil2Paulo Gentil3Fagner M. Alves4Acácia G. F. Leal5Viviane Soares6Viviane Soares7Maria S. Silva8Maria S. Silva9Marcus F. Vieira10Marcus F. Vieira11Karina Simões12Gustavo R. Pedrino13Ana C. S. Rebelo14Ana C. S. Rebelo15School of Medicine, Federal University of GoiásGoiânia, BrazilDepartment of Physical Therapy, Sacred Heart UniversityBauru, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilSchool of Physical Education and Dance, Federal University of GoiásGoiânia, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilDepartment of Morphology, Biological Sciences Institute, Federal University of GoiásGoiânia, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilSchool of Physical Education and Dance, Federal University of GoiásGoiânia, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilSchool of Physical Education and Dance, Federal University of GoiásGoiânia, BrazilEvangelical Educational Association, University Centre of AnápolisAnápolis, BrazilCenter of Neuroscience and Cardiovascular Research, Federal University of GoiásGoiânia, BrazilSchool of Medicine, Federal University of GoiásGoiânia, BrazilEvangelical Educational Association, University Centre of AnápolisAnápolis, BrazilObjective: To test whether women with metabolic syndrome (MS) have impairments in the on- and off-transients during an incremental test and to study whether any of the MS components are independently associated with the observed responses.Research Design and Methods: Thirty-six women aged 35–55 years were divided into a group with MS (MSG, n = 19) and a control group (CG, n = 17). R-R intervals (RRi) and heart rate variability (HRV) were calculated on a beat-to-beat basis and the heart rate (HR) at the on- and off-transient were analyzed during an incremental cardiopulmonary exercise test (CPET).Results: MSG showed lower aerobic capacity and lower parasympathetic cardiac modulation at rest compared with CG. HR values in on-transient phase were significantly lower in MSG compared with CG. The exponential amplitudes “amp” and the parameters “τ” [speed of heart rate recovery (HRR)] were lower in MSG. MSG exhibited higher HR values in comparison to CG during the off-transient indicating a slower HRR. In MSG, there was an inverse and significant correlation between fasting plasma vs. ΔF and glucose vs. exponential “τ” of HRR dynamics.Conclusion: MS is associated with poor heart rate kinetics. The altered HR kinetics seems to be related to alterations in cardiac parasympathetic modulation, and glucose metabolism seems to be the major determinant.http://journal.frontiersin.org/article/10.3389/fphys.2017.00542/fullautonomic dysfunctionfasting glucoseacute and late complicationshigh intensity interval exerciseoxygen consumption |
| spellingShingle | Lucas R. B. E. Silva Antonio R. Zamunér Paulo Gentil Paulo Gentil Fagner M. Alves Acácia G. F. Leal Viviane Soares Viviane Soares Maria S. Silva Maria S. Silva Marcus F. Vieira Marcus F. Vieira Karina Simões Gustavo R. Pedrino Ana C. S. Rebelo Ana C. S. Rebelo Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome Frontiers in Physiology autonomic dysfunction fasting glucose acute and late complications high intensity interval exercise oxygen consumption |
| title | Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome |
| title_full | Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome |
| title_fullStr | Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome |
| title_full_unstemmed | Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome |
| title_short | Cardiac Autonomic Modulation and the Kinetics of Heart Rate Responses in the On- and Off-Transient during Exercise in Women with Metabolic Syndrome |
| title_sort | cardiac autonomic modulation and the kinetics of heart rate responses in the on and off transient during exercise in women with metabolic syndrome |
| topic | autonomic dysfunction fasting glucose acute and late complications high intensity interval exercise oxygen consumption |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00542/full |
| work_keys_str_mv | AT lucasrbesilva cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT antoniorzamuner cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT paulogentil cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT paulogentil cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT fagnermalves cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT acaciagfleal cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT vivianesoares cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT vivianesoares cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT mariassilva cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT mariassilva cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT marcusfvieira cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT marcusfvieira cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT karinasimoes cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT gustavorpedrino cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT anacsrebelo cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome AT anacsrebelo cardiacautonomicmodulationandthekineticsofheartrateresponsesintheonandofftransientduringexerciseinwomenwithmetabolicsyndrome |